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• W2053005914 endingPage "212" @default.
• W2053005914 startingPage "205" @default.
• W2053005914 abstract "The liver is an important and attractive target for the development of gene therapy strategies. Many genetic diseases are manifested in the liver, and both infectious and malignant diseases affect this organ. Retroviral and adenoviral vectors have been shown to infect hepatocytes with varying efficiently in vitro and in vivo. The presence of unique receptors at the cellular membrane of hepatocytes has stimulated the development of transfer strategies based on receptor targeting of vectors. The results of a first clinical trial for gene therapy in the liver based on ex vivo gene delivery has shown both the feasibility and the limits of current technology. This review discusses both existing vectors and strategies and prospective developments towards liver-directed gene therapy of genetic and malignant diseases." @default.
• W2053005914 created "2016-06-24" @default.
• W2053005914 creator A5006169890 @default.
• W2053005914 creator A5033172133 @default.
• W2053005914 date "1996-04-01" @default.
• W2053005914 modified "2023-10-14" @default.
• W2053005914 title "Liver-directed gene transfer and application to therapy" @default.
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• W2053005914 doi "https://doi.org/10.1007/bf00204750" @default.
• W2053005914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8740651" @default.
• W2053005914 hasPublicationYear "1996" @default.
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