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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053008091> ?p ?o ?g. }

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• W2053008091 abstract "Although the adeno-associated virus (AAV) vector is a promising tool for gene transfer into neurons, especially for therapeutic purposes, neurotropism in primate brains is not fully elucidated for specific AAV serotypes. Here, we injected AAV serotype 8 (AAV8) vector carrying the enhanced green fluorescent protein (EGFP) gene under a ubiquitous promoter into the cerebral cortex, striatum and substantia nigra of common marmosets. Robust neuronal EGFP expression was observed at all injected sites. Cell typing with immunohistochemistry confirmed efficient AAV8-mediated gene transfer into the pyramidal neurons in the cortex, calbindin-positive medium spiny neurons in the striatum and dopaminergic neurons in the substantia nigra. The results indicate a preferential tropism of AAV8 for subsets of neurons, but not for glia, in monkey brains." @default.
• W2053008091 created "2016-06-24" @default.
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• W2053008091 date "2010-04-21" @default.
• W2053008091 modified "2023-10-16" @default.
• W2053008091 title "Efficient gene transfer into neurons in monkey brain by adeno-associated virus 8" @default.
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• W2053008091 doi "https://doi.org/10.1097/wnr.0b013e328338ba00" @default.
• W2053008091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20224455" @default.
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