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- W2053008582 abstract "Abstract High-throughput screening techniques for small molecules can find intensive applications in the studies of biosynthesis of these molecules. A sensitive, rapid and cost-effective technique that allows high-throughput screening of endogenous production of the natural iminosugar 1-deoxynojirimycin (1-DNJ), an α-glucosidase inhibitor relevant to the pharmaceutical industry, was developed in this study, based on the inhibitory effects of 1-DNJ on the activity of the β-glycosidase LacS from Sulfolobus solfataricus . This technique has been demonstrated effective in engineering both the key enzyme and the expression levels of enzymes in the 1-DNJ biosynthetic pathway from Bacillus atrophaeus cloned in E. coli . Higher biosynthetic efficiency was achieved using directed evolution strategies." @default.
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- W2053008582 date "2015-02-24" @default.
- W2053008582 modified "2023-09-25" @default.
- W2053008582 title "Design and Application of a Novel High-throughput Screening Technique for 1-Deoxynojirimycin" @default.
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- W2053008582 doi "https://doi.org/10.1038/srep08563" @default.
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