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• W2053009468 abstract "Ventral striatum (VS) is a critical brain region for reinforcement learning and motivation, and VS hypofunction is implicated in psychiatric disorders including schizophrenia. Providing rewards or performance feedback has been shown to activate VS. Intrinsically motivated subjects performing challenging cognitive tasks are likely to engage reinforcement circuitry even in the absence of external feedback or incentives. However, such intrinsic reinforcement responses have received little attention, have not been examined in relation to behavioral performance, and have not been evaluated for impairment in neuropsychiatric disorders such as schizophrenia. Here we used fMRI to examine a challenging old vs. new visual recognition task in healthy subjects and patients with schizophrenia. Targets were unique fractal stimuli previously presented as salient distractors in a visual oddball task, producing incidental memory encoding. Based on the prediction error theory of reinforcement learning, we hypothesized that correct target recognition would activate VS in controls, and that this activation would be greater in subjects with lower expectation of responding correctly as indexed by a more conservative response bias. We also predicted these effects would be reduced in patients with schizophrenia. Consistent with these predictions, controls activated VS and other reinforcement processing regions during correct recognition, with greater VS activation in those with a more conservative response bias. Patients did not show either effect, with significant group differences suggesting hyporesponsivity in patients to internally generated feedback. These findings highlight the importance of accounting for intrinsic motivation and reward when studying cognitive tasks, and add to growing evidence of reward circuit dysfunction in schizophrenia that may impact cognition and function." @default.
• W2053009468 created "2016-06-24" @default.
• W2053009468 creator A5084652393 @default.
• W2053009468 date "2011-01-01" @default.
• W2053009468 modified "2023-10-02" @default.
• W2053009468 title "Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia" @default.
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• W2053009468 doi "https://doi.org/10.3389/fnbeh.2011.00081" @default.
• W2053009468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280525" @default.
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• W2053009468 hasPublicationYear "2011" @default.
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