FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053009552> ?p ?o ?g. }

• W2053009552 endingPage "1105" @default.
• W2053009552 startingPage "1099" @default.
• W2053009552 abstract "We investigated the efficacy of directly injecting a plasmid with complementary DNA encoding human hepatocyte growth factor into ischemic canine myocardium to induce angiogenesis.Four weeks after ligation of the left anterior descending coronary artery, 125 microg of a complementary DNA plasmid encoding the gene for either hepatocyte growth factor (n = 8) or LacZ (transfection control group, n = 8) was injected directly into the myocardium at the border between the normal tissue and the infarction. Eight other dogs were used as a sham control group. Regional thickening fraction, which indicated contractile function, and blood flow in the normal (circumflex branch territory) and ischemic areas were evaluated under dobutamine administration just before and 4 weeks after transfection. The animals were killed, and capillary numbers in both areas were assessed. These data in the ischemic area were evaluated as the percentage of those in the normal.The number of myocardial capillaries in the ischemic area was successfully increased to approximately 140% of usual in the hepatocyte growth factor group, whereas no change was observed in the other groups (P =.0017 by analysis of variance). Furthermore, regional thickening fraction and blood flow in the ischemic area, which had deteriorated after coronary ligation, showed significant improvement in the hepatocyte growth factor group relative to the other groups (thickening fraction P <.0001 by analysis of variance, blood flow P =.0005 by analysis of variance).These results support the efficacy of the direct injection of plasmid complementary DNA encoding human hepatocyte growth factor to induce therapeutic angiogenesis in the ischemic myocardium." @default.
• W2053009552 created "2016-06-24" @default.
• W2053009552 creator A5024876641 @default.
• W2053009552 creator A5045683397 @default.
• W2053009552 creator A5055433147 @default.
• W2053009552 creator A5058261979 @default.
• W2053009552 creator A5071765793 @default.
• W2053009552 creator A5080102542 @default.
• W2053009552 creator A5081056035 @default.
• W2053009552 creator A5089012546 @default.
• W2053009552 date "2002-12-01" @default.
• W2053009552 modified "2023-09-24" @default.
• W2053009552 title "Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor" @default.
• W2053009552 cites W1969055985 @default.
• W2053009552 cites W2002045669 @default.
• W2053009552 cites W2002111141 @default.
• W2053009552 cites W2005782838 @default.
• W2053009552 cites W2025437703 @default.
• W2053009552 cites W2034633555 @default.
• W2053009552 cites W2035174231 @default.
• W2053009552 cites W2040422854 @default.
• W2053009552 cites W2041813473 @default.
• W2053009552 cites W2043852940 @default.
• W2053009552 cites W2044666189 @default.
• W2053009552 cites W2067943009 @default.
• W2053009552 cites W2069400348 @default.
• W2053009552 cites W2077323415 @default.
• W2053009552 cites W2086757889 @default.
• W2053009552 cites W2087461041 @default.
• W2053009552 cites W2092077170 @default.
• W2053009552 cites W2093457985 @default.
• W2053009552 cites W2102634028 @default.
• W2053009552 cites W2114732323 @default.
• W2053009552 cites W2119841264 @default.
• W2053009552 cites W2142401146 @default.
• W2053009552 cites W2143499157 @default.
• W2053009552 cites W2144960281 @default.
• W2053009552 cites W2147135453 @default.
• W2053009552 cites W2164356347 @default.
• W2053009552 cites W4245172576 @default.
• W2053009552 doi "https://doi.org/10.1067/mtc.2002.123809" @default.
• W2053009552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12447174" @default.
• W2053009552 hasPublicationYear "2002" @default.
• W2053009552 type Work @default.
• W2053009552 sameAs 2053009552 @default.
• W2053009552 citedByCount "46" @default.
• W2053009552 countsByYear W20530095522012 @default.
• W2053009552 countsByYear W20530095522013 @default.
• W2053009552 countsByYear W20530095522014 @default.
• W2053009552 countsByYear W20530095522015 @default.
• W2053009552 countsByYear W20530095522016 @default.
• W2053009552 countsByYear W20530095522017 @default.
• W2053009552 countsByYear W20530095522020 @default.
• W2053009552 countsByYear W20530095522022 @default.
• W2053009552 crossrefType "journal-article" @default.
• W2053009552 hasAuthorship W2053009552A5024876641 @default.
• W2053009552 hasAuthorship W2053009552A5045683397 @default.
• W2053009552 hasAuthorship W2053009552A5055433147 @default.
• W2053009552 hasAuthorship W2053009552A5058261979 @default.
• W2053009552 hasAuthorship W2053009552A5071765793 @default.
• W2053009552 hasAuthorship W2053009552A5080102542 @default.
• W2053009552 hasAuthorship W2053009552A5081056035 @default.
• W2053009552 hasAuthorship W2053009552A5089012546 @default.
• W2053009552 hasBestOaLocation W20530095521 @default.
• W2053009552 hasConcept C126322002 @default.
• W2053009552 hasConcept C142724271 @default.
• W2053009552 hasConcept C164705383 @default.
• W2053009552 hasConcept C167734588 @default.
• W2053009552 hasConcept C170493617 @default.
• W2053009552 hasConcept C179437574 @default.
• W2053009552 hasConcept C202751555 @default.
• W2053009552 hasConcept C2775960820 @default.
• W2053009552 hasConcept C2776200302 @default.
• W2053009552 hasConcept C2776996007 @default.
• W2053009552 hasConcept C2777025900 @default.
• W2053009552 hasConcept C2778271429 @default.
• W2053009552 hasConcept C2780394083 @default.
• W2053009552 hasConcept C2781188250 @default.
• W2053009552 hasConcept C55493867 @default.
• W2053009552 hasConcept C71924100 @default.
• W2053009552 hasConcept C86803240 @default.
• W2053009552 hasConceptScore W2053009552C126322002 @default.
• W2053009552 hasConceptScore W2053009552C142724271 @default.
• W2053009552 hasConceptScore W2053009552C164705383 @default.
• W2053009552 hasConceptScore W2053009552C167734588 @default.
• W2053009552 hasConceptScore W2053009552C170493617 @default.
• W2053009552 hasConceptScore W2053009552C179437574 @default.
• W2053009552 hasConceptScore W2053009552C202751555 @default.
• W2053009552 hasConceptScore W2053009552C2775960820 @default.
• W2053009552 hasConceptScore W2053009552C2776200302 @default.
• W2053009552 hasConceptScore W2053009552C2776996007 @default.
• W2053009552 hasConceptScore W2053009552C2777025900 @default.
• W2053009552 hasConceptScore W2053009552C2778271429 @default.
• W2053009552 hasConceptScore W2053009552C2780394083 @default.
• W2053009552 hasConceptScore W2053009552C2781188250 @default.
• W2053009552 hasConceptScore W2053009552C55493867 @default.
• W2053009552 hasConceptScore W2053009552C71924100 @default.
• W2053009552 hasConceptScore W2053009552C86803240 @default.

• next