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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053010478> ?p ?o ?g. }

• W2053010478 endingPage "1641" @default.
• W2053010478 startingPage "1638" @default.
• W2053010478 abstract "The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway." @default.
• W2053010478 created "2016-06-24" @default.
• W2053010478 creator A5028742170 @default.
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• W2053010478 date "1997-11-28" @default.
• W2053010478 modified "2023-10-02" @default.
• W2053010478 title "Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway" @default.
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• W2053010478 doi "https://doi.org/10.1126/science.278.5343.1638" @default.
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• W2053010478 hasPublicationYear "1997" @default.
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