Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053018476> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2053018476 endingPage "745" @default.
- W2053018476 startingPage "741" @default.
- W2053018476 abstract "The genetic locus CDKN2A has been linked to familial melanoma, and mutations or deletions in its coding sequence are seen in some cases of sporadic and familial melanomas. The protein encoded by CDKN2A, p16(INK4a), functions as a negative regulator of cell cycle progression and as a tumor suppressor, but the regulatory mechanisms involved in controlling its expression remain poorly defined.This study tested the hypothesis that UVB irradiation, which transiently inhibits the growth of human melanocytes, is one of the regulators of p16(INK4a) expression.Cultured human melanocytes were irradiated with UVB over a sublethal dosage range, and p16(INK4a) protein and mRNA levels were quantified at varying times thereafter by quantitative immunostaining and by Western and Northern blotting.Levels of p16(INK4a) protein in melanocytes increased significantly after sublethal UVB irradiation as compared with nonirradiated cells. Northern analysis indicated that p16(INK4a) messenger RNA coordinately increased in a dose-dependent manner more than 2-fold in irradiated cells at the tested doses.UVB irradiation transcriptionally activates the expression of p16(INK4a) in cultured human melanocytes. Therefore the growth arrest that occurs with irradiation of melanocytes could be mediated, in part, by upregulation of p16(INK4a). This transient arrest may allow repair of UVB-induced DNA damage before cell division. Conversely, hereditary or acquired defects in CDK4A that give rise to functional insufficiency of p16(INK4a) could permit the premature propagation of melanocytes harboring potentially carcinogenic DNA damage." @default.
- W2053018476 created "2016-06-24" @default.
- W2053018476 creator A5033868959 @default.
- W2053018476 date "2000-05-01" @default.
- W2053018476 modified "2023-10-16" @default.
- W2053018476 title "The expression of p16INK4a, the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation" @default.
- W2053018476 cites W1592215560 @default.
- W2053018476 cites W1983348452 @default.
- W2053018476 cites W2000636509 @default.
- W2053018476 cites W2003759655 @default.
- W2053018476 cites W2038440122 @default.
- W2053018476 cites W2040616051 @default.
- W2053018476 cites W2044240831 @default.
- W2053018476 cites W2066461631 @default.
- W2053018476 cites W2084712389 @default.
- W2053018476 cites W2088831705 @default.
- W2053018476 cites W2090649479 @default.
- W2053018476 cites W2148090903 @default.
- W2053018476 cites W2157033538 @default.
- W2053018476 cites W2158350288 @default.
- W2053018476 doi "https://doi.org/10.1067/mjd.2000.103988" @default.
- W2053018476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10775848" @default.
- W2053018476 hasPublicationYear "2000" @default.
- W2053018476 type Work @default.
- W2053018476 sameAs 2053018476 @default.
- W2053018476 citedByCount "38" @default.
- W2053018476 countsByYear W20530184762012 @default.
- W2053018476 countsByYear W20530184762013 @default.
- W2053018476 countsByYear W20530184762014 @default.
- W2053018476 countsByYear W20530184762015 @default.
- W2053018476 countsByYear W20530184762017 @default.
- W2053018476 countsByYear W20530184762019 @default.
- W2053018476 countsByYear W20530184762022 @default.
- W2053018476 crossrefType "journal-article" @default.
- W2053018476 hasAuthorship W2053018476A5033868959 @default.
- W2053018476 hasConcept C104317684 @default.
- W2053018476 hasConcept C127561419 @default.
- W2053018476 hasConcept C143425029 @default.
- W2053018476 hasConcept C153911025 @default.
- W2053018476 hasConcept C2777658100 @default.
- W2053018476 hasConcept C2778264664 @default.
- W2053018476 hasConcept C2779769559 @default.
- W2053018476 hasConcept C2780265364 @default.
- W2053018476 hasConcept C502942594 @default.
- W2053018476 hasConcept C54355233 @default.
- W2053018476 hasConcept C552990157 @default.
- W2053018476 hasConcept C555283112 @default.
- W2053018476 hasConcept C62112901 @default.
- W2053018476 hasConcept C86803240 @default.
- W2053018476 hasConceptScore W2053018476C104317684 @default.
- W2053018476 hasConceptScore W2053018476C127561419 @default.
- W2053018476 hasConceptScore W2053018476C143425029 @default.
- W2053018476 hasConceptScore W2053018476C153911025 @default.
- W2053018476 hasConceptScore W2053018476C2777658100 @default.
- W2053018476 hasConceptScore W2053018476C2778264664 @default.
- W2053018476 hasConceptScore W2053018476C2779769559 @default.
- W2053018476 hasConceptScore W2053018476C2780265364 @default.
- W2053018476 hasConceptScore W2053018476C502942594 @default.
- W2053018476 hasConceptScore W2053018476C54355233 @default.
- W2053018476 hasConceptScore W2053018476C552990157 @default.
- W2053018476 hasConceptScore W2053018476C555283112 @default.
- W2053018476 hasConceptScore W2053018476C62112901 @default.
- W2053018476 hasConceptScore W2053018476C86803240 @default.
- W2053018476 hasFunder F4320306085 @default.
- W2053018476 hasFunder F4320332161 @default.
- W2053018476 hasFunder F4320332505 @default.
- W2053018476 hasIssue "5" @default.
- W2053018476 hasLocation W20530184761 @default.
- W2053018476 hasLocation W20530184762 @default.
- W2053018476 hasOpenAccess W2053018476 @default.
- W2053018476 hasPrimaryLocation W20530184761 @default.
- W2053018476 hasRelatedWork W1663620072 @default.
- W2053018476 hasRelatedWork W1788793669 @default.
- W2053018476 hasRelatedWork W1991053141 @default.
- W2053018476 hasRelatedWork W2033672302 @default.
- W2053018476 hasRelatedWork W2133919637 @default.
- W2053018476 hasRelatedWork W2268266875 @default.
- W2053018476 hasRelatedWork W2539555867 @default.
- W2053018476 hasRelatedWork W2787582709 @default.
- W2053018476 hasRelatedWork W2966355304 @default.
- W2053018476 hasRelatedWork W3092810516 @default.
- W2053018476 hasVolume "42" @default.
- W2053018476 isParatext "false" @default.
- W2053018476 isRetracted "false" @default.
- W2053018476 magId "2053018476" @default.
- W2053018476 workType "article" @default.