Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053018604> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2053018604 endingPage "254" @default.
- W2053018604 startingPage "249" @default.
- W2053018604 abstract "Ph.Eur. and BP have introduced a dissolution apparatus for suppositories. Suitability of the apparatus for quality control of paracetamol suppositories was evaluated and the effect of experimental conditions on dissolution profiles was studied. Paracetamol suppositories containing 80–500 mg of the drug, on fatty base, were obtained from four manufacturers (A, B, C, D). The diffusion cell was modified by incorporation of an in-built thermoprobe and large difference (up to 1.7°C) between temperature in the water-bath and in the dissolution chamber was observed. This effect was avoided by increasing the length of tubing immersed in the thermostat at the inlet of the cell. The most reproducible results were observed for A and C suppositories, however from suppository C the total dose of paracetamol was released after 3.5–4.5 h while the release from suppository A was slow with only 40–87% of the total dose liberated during 6 h. Suppositories B did not melt at 37°C and less than 5% of the drug was released. Fast release was observed after melting when the temperature was elevated to 39.5°C. The results demonstrate clearly that essentially complete melting of a suppository in the dissolution chamber is required for an appropriate dissolution of paracetamol in vitro. Disintegration time, softening time, drop point and particle size of the suspended drug were measured and the relevance of these parameters for dissolution behaviour of the preparations was discussed." @default.
- W2053018604 created "2016-06-24" @default.
- W2053018604 creator A5023857862 @default.
- W2053018604 creator A5031601507 @default.
- W2053018604 creator A5054068537 @default.
- W2053018604 creator A5068117824 @default.
- W2053018604 creator A5088074494 @default.
- W2053018604 date "2001-09-01" @default.
- W2053018604 modified "2023-10-16" @default.
- W2053018604 title "Evaluation of paracetamol suppositories by a pharmacopoeial dissolution test – comments on methodology" @default.
- W2053018604 cites W134301846 @default.
- W2053018604 cites W166362531 @default.
- W2053018604 cites W2021589138 @default.
- W2053018604 cites W2050713826 @default.
- W2053018604 cites W2087610817 @default.
- W2053018604 cites W2127286203 @default.
- W2053018604 cites W348441954 @default.
- W2053018604 cites W2324442567 @default.
- W2053018604 doi "https://doi.org/10.1016/s0939-6411(01)00187-4" @default.
- W2053018604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11522493" @default.
- W2053018604 hasPublicationYear "2001" @default.
- W2053018604 type Work @default.
- W2053018604 sameAs 2053018604 @default.
- W2053018604 citedByCount "24" @default.
- W2053018604 countsByYear W20530186042012 @default.
- W2053018604 countsByYear W20530186042013 @default.
- W2053018604 countsByYear W20530186042014 @default.
- W2053018604 countsByYear W20530186042015 @default.
- W2053018604 countsByYear W20530186042016 @default.
- W2053018604 countsByYear W20530186042017 @default.
- W2053018604 countsByYear W20530186042018 @default.
- W2053018604 countsByYear W20530186042019 @default.
- W2053018604 countsByYear W20530186042020 @default.
- W2053018604 countsByYear W20530186042022 @default.
- W2053018604 countsByYear W20530186042023 @default.
- W2053018604 crossrefType "journal-article" @default.
- W2053018604 hasAuthorship W2053018604A5023857862 @default.
- W2053018604 hasAuthorship W2053018604A5031601507 @default.
- W2053018604 hasAuthorship W2053018604A5054068537 @default.
- W2053018604 hasAuthorship W2053018604A5068117824 @default.
- W2053018604 hasAuthorship W2053018604A5088074494 @default.
- W2053018604 hasConcept C14029885 @default.
- W2053018604 hasConcept C178790620 @default.
- W2053018604 hasConcept C185592680 @default.
- W2053018604 hasConcept C2778042862 @default.
- W2053018604 hasConcept C2781430271 @default.
- W2053018604 hasConcept C43617362 @default.
- W2053018604 hasConcept C71924100 @default.
- W2053018604 hasConcept C77281830 @default.
- W2053018604 hasConcept C88380143 @default.
- W2053018604 hasConcept C98274493 @default.
- W2053018604 hasConceptScore W2053018604C14029885 @default.
- W2053018604 hasConceptScore W2053018604C178790620 @default.
- W2053018604 hasConceptScore W2053018604C185592680 @default.
- W2053018604 hasConceptScore W2053018604C2778042862 @default.
- W2053018604 hasConceptScore W2053018604C2781430271 @default.
- W2053018604 hasConceptScore W2053018604C43617362 @default.
- W2053018604 hasConceptScore W2053018604C71924100 @default.
- W2053018604 hasConceptScore W2053018604C77281830 @default.
- W2053018604 hasConceptScore W2053018604C88380143 @default.
- W2053018604 hasConceptScore W2053018604C98274493 @default.
- W2053018604 hasIssue "2" @default.
- W2053018604 hasLocation W20530186041 @default.
- W2053018604 hasLocation W20530186042 @default.
- W2053018604 hasOpenAccess W2053018604 @default.
- W2053018604 hasPrimaryLocation W20530186041 @default.
- W2053018604 hasRelatedWork W2007518524 @default.
- W2053018604 hasRelatedWork W2015482575 @default.
- W2053018604 hasRelatedWork W2053018604 @default.
- W2053018604 hasRelatedWork W2082352425 @default.
- W2053018604 hasRelatedWork W2086283345 @default.
- W2053018604 hasRelatedWork W2351291342 @default.
- W2053018604 hasRelatedWork W2391379785 @default.
- W2053018604 hasRelatedWork W2728931057 @default.
- W2053018604 hasRelatedWork W2791896977 @default.
- W2053018604 hasRelatedWork W3095629540 @default.
- W2053018604 hasVolume "52" @default.
- W2053018604 isParatext "false" @default.
- W2053018604 isRetracted "false" @default.
- W2053018604 magId "2053018604" @default.
- W2053018604 workType "article" @default.