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• W2053018786 endingPage "410" @default.
• W2053018786 startingPage "394" @default.
• W2053018786 abstract "We present a novel mouse-model for the study of skeletal structure and evolution, based on selective breeding for high levels of voluntary wheel running. Whereas traditional models (originally inbred strains, more recently knockouts and transgenics) rely on the study of mutant or laboratory-manipulated phenotypes, we have studied changes in skeletal morphometrics resulting from many generations of artificial selection for high activity in the form of wheel running, in which mice engage voluntarily. Mice from the four replicate High Runner (HR) lines run nearly three times as many revolutions during days 5 and 6 of a 6-day exposure to wheels (1.12 m circumference). We have found significant changes in skeletal dimensions of the hind limbs, including decreased directional asymmetry, larger femoral heads, and wider distal femora. The latter two have been hypothesized as evolutionary adaptations for long-distance locomotion in hominids. Exercise-training studies involving experimental groups with and without access to wheels have shown increased diameters of both femora and tibiafibulae, and suggest genetic effects on trainability (genotype-by-environment interactions). Reanalysis of previously published data on bone masses of hind limbs revealed novel patterns of change in bone mass associated with access to wheels for 2 months. Without access to wheels, HR mice have significantly heavier tibiafibulae and foot bones, whereas with chronic access to wheels, a significant increase in foot bone mass that was linearly related to increases in daily wheel running was observed. Mice exhibiting a recently discovered small-muscle phenotype (mini-muscle, [MM] caused by a Mendelian recessive gene), in which the mass of the triceps surae muscle complex is ∼50% lower than in normal individuals, have significantly longer and thinner bones in the hind limb. We present new data for the ontogenetic development of muscle mass in Control, HR, and MM phenotypes in mice of 1-7 weeks postnatal age. Statistical comparisons reveal highly significant differences both in triceps surae mass and mass-corrected triceps surae mass between normal and MM mice at all but the postnatal age of 1 week. Based on previously observed differences in distributions of myosin isoforms in adult MM mice, we hypothesize that a reduction of myosin heavy-chain type-IIb isoforms with accounts for our observed ontogenetic changes in muscle mass." @default.
• W2053018786 created "2016-06-24" @default.
• W2053018786 creator A5019388483 @default.
• W2053018786 creator A5030321099 @default.
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• W2053018786 date "2008-06-18" @default.
• W2053018786 modified "2023-10-15" @default.
• W2053018786 title "Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice" @default.
• W2053018786 cites W1490193151 @default.
• W2053018786 cites W1548178315 @default.
• W2053018786 cites W162252972 @default.
• W2053018786 cites W1858418965 @default.
• W2053018786 cites W1905920866 @default.
• W2053018786 cites W1948556888 @default.
• W2053018786 cites W1963690512 @default.
• W2053018786 cites W1965635919 @default.
• W2053018786 cites W1968605841 @default.
• W2053018786 cites W1971817436 @default.
• W2053018786 cites W1973502921 @default.
• W2053018786 cites W1974315061 @default.
• W2053018786 cites W1974660743 @default.
• W2053018786 cites W1975636294 @default.
• W2053018786 cites W1977379015 @default.
• W2053018786 cites W1980740451 @default.
• W2053018786 cites W1982210313 @default.
• W2053018786 cites W1982855130 @default.
• W2053018786 cites W1987083735 @default.
• W2053018786 cites W1989532264 @default.
• W2053018786 cites W1997612931 @default.
• W2053018786 cites W1998198644 @default.
• W2053018786 cites W1998572033 @default.
• W2053018786 cites W2002934579 @default.
• W2053018786 cites W2005190322 @default.
• W2053018786 cites W2008028279 @default.
• W2053018786 cites W2008799196 @default.
• W2053018786 cites W2010929467 @default.
• W2053018786 cites W2011404595 @default.
• W2053018786 cites W2013914899 @default.
• W2053018786 cites W2014991301 @default.
• W2053018786 cites W2015050458 @default.
• W2053018786 cites W2015701339 @default.
• W2053018786 cites W2017421512 @default.
• W2053018786 cites W2017587984 @default.
• W2053018786 cites W2023744940 @default.
• W2053018786 cites W2026889605 @default.
• W2053018786 cites W2027795399 @default.
• W2053018786 cites W2028061789 @default.
• W2053018786 cites W2032697567 @default.
• W2053018786 cites W2032875206 @default.
• W2053018786 cites W2035931594 @default.
• W2053018786 cites W2036007066 @default.
• W2053018786 cites W2036338634 @default.
• W2053018786 cites W2037499635 @default.
• W2053018786 cites W2039591083 @default.
• W2053018786 cites W2042126703 @default.
• W2053018786 cites W2043567886 @default.
• W2053018786 cites W2047556103 @default.
• W2053018786 cites W2048047184 @default.
• W2053018786 cites W2048562320 @default.
• W2053018786 cites W2049104887 @default.
• W2053018786 cites W2050799088 @default.
• W2053018786 cites W2051613367 @default.
• W2053018786 cites W2052678291 @default.
• W2053018786 cites W2054368198 @default.
• W2053018786 cites W2055535789 @default.
• W2053018786 cites W2056301653 @default.
• W2053018786 cites W2058725004 @default.
• W2053018786 cites W2060938790 @default.
• W2053018786 cites W2061881547 @default.
• W2053018786 cites W2064985760 @default.
• W2053018786 cites W2066317938 @default.
• W2053018786 cites W2071015998 @default.
• W2053018786 cites W2071246329 @default.
• W2053018786 cites W2072490838 @default.
• W2053018786 cites W2072658479 @default.
• W2053018786 cites W2073459232 @default.
• W2053018786 cites W2075462980 @default.
• W2053018786 cites W2076085495 @default.
• W2053018786 cites W2077974816 @default.
• W2053018786 cites W2079243690 @default.
• W2053018786 cites W2080361330 @default.
• W2053018786 cites W2085724937 @default.
• W2053018786 cites W2086005052 @default.
• W2053018786 cites W2086694435 @default.
• W2053018786 cites W2087929520 @default.
• W2053018786 cites W2090241995 @default.
• W2053018786 cites W2094502595 @default.
• W2053018786 cites W2097531156 @default.
• W2053018786 cites W2098750595 @default.
• W2053018786 cites W2101180570 @default.
• W2053018786 cites W2103311381 @default.
• W2053018786 cites W2103548606 @default.
• W2053018786 cites W2103737135 @default.
• W2053018786 cites W2105225554 @default.
• W2053018786 cites W2105696044 @default.
• W2053018786 cites W2106225750 @default.
• W2053018786 cites W2115190197 @default.
• W2053018786 cites W2116570972 @default.

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