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- W2053034388 startingPage "3341" @default.
- W2053034388 abstract "Osteoclasts are bone-resorbing cells of monocytic origin. An imbalance between bone formation and resorption can lead to osteoporosis or osteopetrosis. Osteoclastogenesis is triggered by RANKL- and IP3-induced Ca(2+) influx followed by activation of NFATc1, a master transcription factor for osteoclastogenic gene regulation. During differentiation, osteoclasts undergo cytoskeletal remodeling to migrate and attach to the bone surface. Simultaneously, they fuse with each other to form multinucleated cells. These processes require PI3-kinase-dependent cytoskeletal protein activation to initiate cytoskeletal remodeling, resulting in the formation of circumferential podosomes and fusion-competent protrusions. In multinucleated osteoclasts, circumferential podosomes mature into stabilized actin rings, which enables the formation of a ruffled border where intensive membrane trafficking is executed. Membrane lipids, especially phosphoinositides, are key signaling molecules that regulate osteoclast morphology and act as second messengers and docking sites for multiple important effectors. We examine the critical roles of phosphoinositides in the signaling cascades that regulate osteoclast functions." @default.
- W2053034388 created "2016-06-24" @default.
- W2053034388 creator A5020149551 @default.
- W2053034388 creator A5040648686 @default.
- W2053034388 creator A5060011008 @default.
- W2053034388 date "2013-01-08" @default.
- W2053034388 modified "2023-10-14" @default.
- W2053034388 title "Regulation of osteoclasts by membrane-derived lipid mediators" @default.
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