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• W2053040360 abstract "We investigated effects of flecainide, a Class IC sodium channel blocker, in the rat chronic constrictive injury (CCI) and ectopic nerve discharge models. In the behavioral evaluation, 2, 6, and 12 mg/kg flecainide were intravenously given to the CCI model, and a dose-dependent analgesic effect was shown on both thermal hyperalgesia and tactile allodynia. In the electrophysiological evaluation using the ectopic nerve discharge model produced by saphenous neurectomy, i.v. administration of 2, 6, and 12 mg/kg flecainide suppressed spontaneous discharge at the peripheral nerve level in a dose-dependent fashion as with the behavioral evaluation, but flecainide did not affect nerve conduction at the dose of 12 mg/kg." @default.
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• W2053040360 date "2001-07-01" @default.
• W2053040360 modified "2023-09-24" @default.
• W2053040360 title "Flecainide reverses neuropathic pain and suppresses ectopic nerve discharge in rats" @default.
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• W2053040360 doi "https://doi.org/10.1097/00001756-200107030-00021" @default.
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