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- W2053081570 abstract "Abstract The intravenous injection of fructose (200 or 400 mg) into the anesthetized rat leads to a prompt increase in the hepatic α-glycerophosphate concentration. However, this increase is transient since the α-glycerophosphate concentration returns to control levels within 20 min after fructose injection. Analysis of the plasma fructose concentration at this time shows that the fall in the hepatic α-glycerophosphate concentration cannot be due to a lack of substrate for fructokinase (EC 2.7.1.3). The changes in the hepatic pyruvate concentration after intravenous fructose mirrored those for α-glycerophosphate. In comparison to fructose, glucose injection did not lead to an early increase in the hepatic α-glycerophosphate concentration. 20 min after intravenous glucose, the hepatic α-glycerophosphate concentration was nearly 2-fold greater than the control values. The data indicate that the effects of fructose on hepatic fatty acid metabolism cannot be related to sustained increases in hepatic α-glycerophosphate concentration. They also demonstrate that under certain conditions, the hepatic α-glycerophosphate concentration may be greater after glucose than after fructose administration." @default.
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- W2053081570 date "1968-10-01" @default.
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- W2053081570 title "The effect of intravenous fructose and glucose on the hepatic α-glycerophosphate concentration in the rat" @default.
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- W2053081570 doi "https://doi.org/10.1016/0304-4165(68)90215-8" @default.
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