Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053085163> ?p ?o ?g. }
- W2053085163 endingPage "980" @default.
- W2053085163 startingPage "971" @default.
- W2053085163 abstract "The original mcm1-1 mutant was identified by its inability to propagate minichromosomes in an ARS-specific manner, suggesting that it is defective in the initiation of DNA synthesis at ARSs. This mutant is also defective in expression of alpha-mating-type-specific genes. Further genetic and biochemical studies confirmed that Mcm1 is a transcription factor that mediates the transcriptional regulation of a number of genes, including genes outside of the mating type complement, by interacting with different cofactors. Although MCM1 is an essential gene, none of the previously characterized mcm1 mutants exhibits significant growth defects. To assess which of the many roles of Mcm1 is essential for growth, we constructed and characterized a temperature-sensitive conditional mutant of mcm1, mcm1-110L. This mutant exhibits a temperature-dependent cell-cycle arrest, with a large, elongated bud and a single, undivided nucleus that has a DNA content of close to 2n. In addition, it shows elevated levels of chromosome loss and recombination. In spite of the severity of the mcm1-110L mutation, this mutant still retains an ARS-specific pattern of minichromosome instability. All of these phenotypes are precisely those exhibited by mutants in three MCM genes, MCM2, MCM3, and MCM5/CDC46, that have been shown to play interacting roles in the early steps of DNA replication." @default.
- W2053085163 created "2016-06-24" @default.
- W2053085163 creator A5049724219 @default.
- W2053085163 creator A5055181732 @default.
- W2053085163 date "1992-09-01" @default.
- W2053085163 modified "2023-10-14" @default.
- W2053085163 title "Chromosome loss, hyperrecombination, and cell cycle arrest in a yeast mcm1 mutant." @default.
- W2053085163 cites W1221384716 @default.
- W2053085163 cites W1484383644 @default.
- W2053085163 cites W1573365260 @default.
- W2053085163 cites W1755034206 @default.
- W2053085163 cites W1811606715 @default.
- W2053085163 cites W1907280881 @default.
- W2053085163 cites W1916002325 @default.
- W2053085163 cites W1945304539 @default.
- W2053085163 cites W1967004332 @default.
- W2053085163 cites W1969737313 @default.
- W2053085163 cites W1976128043 @default.
- W2053085163 cites W1982061874 @default.
- W2053085163 cites W1982910659 @default.
- W2053085163 cites W1996380608 @default.
- W2053085163 cites W2003798106 @default.
- W2053085163 cites W2003893812 @default.
- W2053085163 cites W2004008931 @default.
- W2053085163 cites W2009230618 @default.
- W2053085163 cites W2013061140 @default.
- W2053085163 cites W2020672093 @default.
- W2053085163 cites W2033825826 @default.
- W2053085163 cites W2039307706 @default.
- W2053085163 cites W2047810769 @default.
- W2053085163 cites W2056627100 @default.
- W2053085163 cites W2058161613 @default.
- W2053085163 cites W2059110341 @default.
- W2053085163 cites W2072986600 @default.
- W2053085163 cites W2073499220 @default.
- W2053085163 cites W2075227844 @default.
- W2053085163 cites W2079771997 @default.
- W2053085163 cites W2083181195 @default.
- W2053085163 cites W2083191700 @default.
- W2053085163 cites W2084815044 @default.
- W2053085163 cites W2099666936 @default.
- W2053085163 cites W2101448549 @default.
- W2053085163 cites W2107140925 @default.
- W2053085163 cites W2107372552 @default.
- W2053085163 cites W2116289234 @default.
- W2053085163 cites W2123599906 @default.
- W2053085163 cites W2126909443 @default.
- W2053085163 cites W2134486677 @default.
- W2053085163 cites W2144042585 @default.
- W2053085163 cites W2159268545 @default.
- W2053085163 cites W2188548307 @default.
- W2053085163 cites W2234003373 @default.
- W2053085163 cites W2281445265 @default.
- W2053085163 doi "https://doi.org/10.1091/mbc.3.9.971" @default.
- W2053085163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/275658" @default.
- W2053085163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1421579" @default.
- W2053085163 hasPublicationYear "1992" @default.
- W2053085163 type Work @default.
- W2053085163 sameAs 2053085163 @default.
- W2053085163 citedByCount "37" @default.
- W2053085163 countsByYear W20530851632013 @default.
- W2053085163 countsByYear W20530851632014 @default.
- W2053085163 countsByYear W20530851632015 @default.
- W2053085163 countsByYear W20530851632022 @default.
- W2053085163 countsByYear W20530851632023 @default.
- W2053085163 crossrefType "journal-article" @default.
- W2053085163 hasAuthorship W2053085163A5049724219 @default.
- W2053085163 hasAuthorship W2053085163A5055181732 @default.
- W2053085163 hasBestOaLocation W20530851632 @default.
- W2053085163 hasConcept C104317684 @default.
- W2053085163 hasConcept C143065580 @default.
- W2053085163 hasConcept C151158763 @default.
- W2053085163 hasConcept C175248279 @default.
- W2053085163 hasConcept C2780091387 @default.
- W2053085163 hasConcept C30481170 @default.
- W2053085163 hasConcept C54355233 @default.
- W2053085163 hasConcept C58337764 @default.
- W2053085163 hasConcept C73573662 @default.
- W2053085163 hasConcept C86339819 @default.
- W2053085163 hasConcept C86803240 @default.
- W2053085163 hasConcept C95444343 @default.
- W2053085163 hasConcept C98086919 @default.
- W2053085163 hasConceptScore W2053085163C104317684 @default.
- W2053085163 hasConceptScore W2053085163C143065580 @default.
- W2053085163 hasConceptScore W2053085163C151158763 @default.
- W2053085163 hasConceptScore W2053085163C175248279 @default.
- W2053085163 hasConceptScore W2053085163C2780091387 @default.
- W2053085163 hasConceptScore W2053085163C30481170 @default.
- W2053085163 hasConceptScore W2053085163C54355233 @default.
- W2053085163 hasConceptScore W2053085163C58337764 @default.
- W2053085163 hasConceptScore W2053085163C73573662 @default.
- W2053085163 hasConceptScore W2053085163C86339819 @default.
- W2053085163 hasConceptScore W2053085163C86803240 @default.
- W2053085163 hasConceptScore W2053085163C95444343 @default.
- W2053085163 hasConceptScore W2053085163C98086919 @default.
- W2053085163 hasIssue "9" @default.
- W2053085163 hasLocation W20530851631 @default.
- W2053085163 hasLocation W20530851632 @default.