FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053085424> ?p ?o ?g. }

• W2053085424 endingPage "652" @default.
• W2053085424 startingPage "643" @default.
• W2053085424 abstract "The development of anticancer vaccines requires the identification of unique epitope markers, preferably expressed exclusively on the surface of cancer cells. This Account describes the path of development of a carbohydrate-based vaccine for metastatic breast cancer, including the selection and synthesis of Globo-H as the target, the development of the vaccine conjugate and adjuvant design, the study of the immune response and consideration of class switch, and the analysis of Globo-H distribution on the surface of various cancer cells, cancer stem cells, and normal cells. The first synthesis of Globo-H was accomplished through the use of glycal chemistry; this approach delivered sufficient material for evaluation in phase I human trials. The development of a programmable one-pot synthesis method rendered the synthesis more practical and enabled the midstage proof-of-concept phase II trial and late-stage phase III trial. Finally, enzymatic synthesis of Globo-H coupled with cofactor regeneration was used for the late-stage multicenter trials and manufacture of the product. Along this path of development, it was discovered that the vaccine induced antibodies to target not only Globo-H, but also SSEA3 and SSEA4. Moreover, these three glycolipids were found to be uniquely expressed not only on the cell surface of breast cancer but on 15 additional cancer types, suggesting the broad application of this vaccine in cancer treatment and perhaps cancer prevention. In addition, a new glycolipid adjuvant was designed to target the CD1d receptor on dendritic cells and B cells for presentation to and activation of T cells to modulate the immune response and induce a class switch from IgM to IgG, thereby overcoming the common problem of carbohydrate-based vaccines that often induce mainly IgM antibodies. As demonstrated in this vaccine development, the chemical approach to the synthesis and conjugation of carbohydrate-based immunogens provides the flexibility for access to various structures and linkers to identify optimal compositions for development. The enzymatic method was then introduced to enable the practical synthesis of the vaccine candidate for clinical development and commercialization. Overall, this Account illustrates the path of development of a cancer vaccine, from selection of a unique glycan marker on breast cancer cells and the cancer stem cells as target to the use of chemistry in combination with immunology and cancer biology to enable the design and development of the Globo-H vaccine to target three specific glycan markers exclusively expressed on the cell surface of a number of different types of cancer." @default.
• W2053085424 created "2016-06-24" @default.
• W2053085424 creator A5010176846 @default.
• W2053085424 creator A5032095777 @default.
• W2053085424 creator A5032688567 @default.
• W2053085424 creator A5080191966 @default.
• W2053085424 date "2015-02-10" @default.
• W2053085424 modified "2023-10-18" @default.
• W2053085424 title "Development of Globo-H Cancer Vaccine" @default.
• W2053085424 cites W1569852946 @default.
• W2053085424 cites W1593582113 @default.
• W2053085424 cites W1866549327 @default.
• W2053085424 cites W1964243035 @default.
• W2053085424 cites W1965423278 @default.
• W2053085424 cites W1968196198 @default.
• W2053085424 cites W2026182304 @default.
• W2053085424 cites W2026813736 @default.
• W2053085424 cites W2028854304 @default.
• W2053085424 cites W2044535505 @default.
• W2053085424 cites W2054777120 @default.
• W2053085424 cites W2073080680 @default.
• W2053085424 cites W2085053191 @default.
• W2053085424 cites W2099543897 @default.
• W2053085424 cites W2099635508 @default.
• W2053085424 cites W2119767370 @default.
• W2053085424 cites W2123501358 @default.
• W2053085424 cites W2168711622 @default.
• W2053085424 cites W2175594908 @default.
• W2053085424 cites W2586568545 @default.
• W2053085424 cites W2950021538 @default.
• W2053085424 cites W3127349307 @default.
• W2053085424 doi "https://doi.org/10.1021/ar5004187" @default.
• W2053085424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25665650" @default.
• W2053085424 hasPublicationYear "2015" @default.
• W2053085424 type Work @default.
• W2053085424 sameAs 2053085424 @default.
• W2053085424 citedByCount "166" @default.
• W2053085424 countsByYear W20530854242015 @default.
• W2053085424 countsByYear W20530854242016 @default.
• W2053085424 countsByYear W20530854242017 @default.
• W2053085424 countsByYear W20530854242018 @default.
• W2053085424 countsByYear W20530854242019 @default.
• W2053085424 countsByYear W20530854242020 @default.
• W2053085424 countsByYear W20530854242021 @default.
• W2053085424 countsByYear W20530854242022 @default.
• W2053085424 countsByYear W20530854242023 @default.
• W2053085424 crossrefType "journal-article" @default.
• W2053085424 hasAuthorship W2053085424A5010176846 @default.
• W2053085424 hasAuthorship W2053085424A5032095777 @default.
• W2053085424 hasAuthorship W2053085424A5032688567 @default.
• W2053085424 hasAuthorship W2053085424A5080191966 @default.
• W2053085424 hasBestOaLocation W20530854241 @default.
• W2053085424 hasConcept C121608353 @default.
• W2053085424 hasConcept C126322002 @default.
• W2053085424 hasConcept C147483822 @default.
• W2053085424 hasConcept C185592680 @default.
• W2053085424 hasConcept C195616568 @default.
• W2053085424 hasConcept C203014093 @default.
• W2053085424 hasConcept C2777701055 @default.
• W2053085424 hasConcept C2777863537 @default.
• W2053085424 hasConcept C2778378633 @default.
• W2053085424 hasConcept C502942594 @default.
• W2053085424 hasConcept C71924100 @default.
• W2053085424 hasConcept C86803240 @default.
• W2053085424 hasConcept C8891405 @default.
• W2053085424 hasConcept C96232424 @default.
• W2053085424 hasConceptScore W2053085424C121608353 @default.
• W2053085424 hasConceptScore W2053085424C126322002 @default.
• W2053085424 hasConceptScore W2053085424C147483822 @default.
• W2053085424 hasConceptScore W2053085424C185592680 @default.
• W2053085424 hasConceptScore W2053085424C195616568 @default.
• W2053085424 hasConceptScore W2053085424C203014093 @default.
• W2053085424 hasConceptScore W2053085424C2777701055 @default.
• W2053085424 hasConceptScore W2053085424C2777863537 @default.
• W2053085424 hasConceptScore W2053085424C2778378633 @default.
• W2053085424 hasConceptScore W2053085424C502942594 @default.
• W2053085424 hasConceptScore W2053085424C71924100 @default.
• W2053085424 hasConceptScore W2053085424C86803240 @default.
• W2053085424 hasConceptScore W2053085424C8891405 @default.
• W2053085424 hasConceptScore W2053085424C96232424 @default.
• W2053085424 hasIssue "3" @default.
• W2053085424 hasLocation W20530854241 @default.
• W2053085424 hasLocation W20530854242 @default.
• W2053085424 hasOpenAccess W2053085424 @default.
• W2053085424 hasPrimaryLocation W20530854241 @default.
• W2053085424 hasRelatedWork W2090324576 @default.
• W2053085424 hasRelatedWork W2176718959 @default.
• W2053085424 hasRelatedWork W2378785636 @default.
• W2053085424 hasRelatedWork W2605202598 @default.
• W2053085424 hasRelatedWork W2989802872 @default.
• W2053085424 hasRelatedWork W3168092052 @default.
• W2053085424 hasRelatedWork W4283731173 @default.
• W2053085424 hasRelatedWork W4291367166 @default.
• W2053085424 hasRelatedWork W4308359949 @default.
• W2053085424 hasRelatedWork W4381082016 @default.
• W2053085424 hasVolume "48" @default.
• W2053085424 isParatext "false" @default.
• W2053085424 isRetracted "false" @default.

• next