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- W2053089208 abstract "1. The specific binding of [3H]Nip and [3H]GABA to rat brain membranes has been reexamined.2. Specific binding of [3H]Nip and [3H]GABA was exclusively dependent on sodium ions in a cooperative manner (Hill coefficient 2.2±0.2 and 2.4±0.3 for [3H]Nip and [3H]GABA binding, respectively). Potassium, lithium or choline chloride salts were ineffective for replacing NaCl.3. Maximal binding was observed at 2°C. The association constants were K+1 = 0.033 min−1μM−1 for [3H]GABA. The dissociation constants obtained by the addition of 1 mM of non-labeled GABA were 0.087±0.01 min−1 and 0.139±0.025 min−1 for [3H]Nip and [3H]GABA, respectively. Scatchard curves were in agreement with these constants, KD = 1.6 μM for [3H]GABA and 2.6 μM for [3H]Nip with equal Bmax = 138 pmol per mg protein.4. The dissociation constants for [3H]Nip bound increased from 0 to 0.035, 0.18 and 0.58 min−1 at 2, 16, 26 and 37°C, respectively, contrary to the hydrophobic derivate of nipecotic acid, NO 328.5. Pharmacological characterization and regional brain distribution of [3H]Nip and [3H]GABA binding and uptake, suggest that [3H]Nip specifically labels the neuronal GABA uptake system, absent in peripheral tissues." @default.
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- W2053089208 title "The effects of harmaline on GABA fluxes in pinched-off nerve endings" @default.
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- W2053089208 doi "https://doi.org/10.1016/0006-8993(76)90064-0" @default.
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