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• W2053117941 abstract "Objective . To investigate the pathophysiological role of pro- and anti-inflammatory cytokines in primary multiple sclerosis-related fatigue. Methods . Fatigued and non-fatigued patients with multiple sclerosis (MS) were recruited and their cytokine profiles compared. Patients with secondary fatigue were excluded. Fatigue was assessed with the self-reported Checklist Individual Strength (CIS20r), subscale fatigue. A CIS20r fatigue cut-off score of 35 was applied to differentiate between non-fatigued (CIS20r fatigue<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo>≤</mml:mo></mml:mrow></mml:math>34) and fatigued (CIS20r fatigue<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mo>≥</mml:mo></mml:mrow></mml:math>35) patients with MS. Blood was collected to determine the serum concentrations of pro-inflammatory cytokines (IL-1 β , IL-2, IL-6, IL-8, IL-12p70, IL-17, TNF α , and IFN- γ ) and anti-inflammatory cytokines (IL-4, IL-5, IL-10, and IL-13). We controlled for the confounding effect of age, gender, duration of MS, disease severity, type of MS, and use of immunomodulatory drugs. Results . Similar cytokine levels were observed between MS patients with<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>21</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>and without fatigue<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>14</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Adjusted multiple regression analyses showed a single significant positive relationship, that of IL-6 with CIS20r fatigue score. The explained variance of the IL-6 model was 21.1%, once adjusted for the confounding effect of age. Conclusion . The pro-inflammatory cytokine interleukin-6 (IL-6) may play a role in the pathophysiology of primary fatigue in patients with MS. Trial Registrations . ISRCTN69520623 , ISRCTN58583714 , and ISRCTN82353628 ." @default.
• W2053117941 created "2016-06-24" @default.
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• W2053117941 date "2015-01-01" @default.
• W2053117941 modified "2023-09-26" @default.
• W2053117941 title "Fatigue in Patients with Multiple Sclerosis: Is It Related to Pro- and Anti-Inflammatory Cytokines?" @default.
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• W2053117941 doi "https://doi.org/10.1155/2015/758314" @default.
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