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- W2053131185 abstract "Triterpenoids are used for medicinal purposes in many countries. Some, such as oleanolic and glycyrrhetinic acids, are known to be anti-inflammatory and anticarcinogenic. However, the biological activities of these naturally occurring molecules against their particular targets are weak, so the synthesis of new synthetic analogues with enhanced potency is needed. By combining modifications to both the A and C rings of 18βH-glycyrrhetinic acid, the novel synthetic derivative methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2)-dien-30-oate was obtained. This derivative displays high antiproliferative activity in cancer cells, including a cell line with a multidrug-resistance phenotype. It causes cell death by inducing the intrinsic caspase-dependent apoptotic pathway." @default.
- W2053131185 created "2016-06-24" @default.
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- W2053131185 date "2011-02-15" @default.
- W2053131185 modified "2023-10-04" @default.
- W2053131185 title "Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives" @default.
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- W2053131185 doi "https://doi.org/10.1002/cbic.201000618" @default.
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