FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053156659> ?p ?o ?g. }

• W2053156659 endingPage "229" @default.
• W2053156659 startingPage "222" @default.
• W2053156659 abstract "Abstract We developed a powerful cytotoxic analogue of bombesin AN‐215, in which the bombesin (BN)‐like carrier peptide is conjugated to 2‐pyrrolino doxorubicin (AN‐201). Human prostate cancers express high levels of receptors for BN/gastrin releasing peptide (GRP) that can be used for targeted chemotherapy. The effects of targeted chemotherapy with cytotoxic BN analogue AN‐215 were evaluated in nude mice bearing subcutaneous xenografts of DU‐145, LuCaP‐35, MDA‐PCa‐2b and intraosseous implants of C4‐2 human prostate cancers. Intraosseous growth of C4‐2 tumors was monitored by serum PSA. BN/GRP receptors were evaluated by 125 I‐[Tyr 4 ]BN binding assays and RT‐PCR. The effects of AN‐215 on apoptosis and cell proliferation were followed by histology, and the expression of Bcl‐2 and Bax protein was determined by Western blot analysis. Targeted analog AN‐215 significantly inhibited growth of subcutaneously implanted DU‐145, LuCaP‐35 and MDA‐PCa‐2b prostate cancers by 81% to 91% compared to controls, while cytotoxic radical AN‐201 was less effective and more toxic. Serum PSA levels of mice bearing intraosseous C4‐2 prostate tumors were significantly reduced. In LuCaP‐35 tumors administration of BN antagonist RC‐3095 prior to AN‐215 blocked the receptors for BN/GRP and inhibited the effects of AN‐215. High affinity receptors for BN/GRP and their m‐RNA were detected on membranes of all 4 tumor models. Therapy with AN‐215, but not with AN‐201, decreased the ratio of Bcl‐2/Bax in DU‐145 and the expression of antiapoptotic Bcl‐2 in LuCaP‐35 tumors. The presence of BN/GRP receptors on primary and metastatic prostate cancers makes possible targeted chemotherapy with AN‐215 for the treatment of this malignancy. © 2005 Wiley‐Liss, Inc." @default.
• W2053156659 created "2016-06-24" @default.
• W2053156659 creator A5008707617 @default.
• W2053156659 creator A5013036085 @default.
• W2053156659 creator A5018745405 @default.
• W2053156659 creator A5020268469 @default.
• W2053156659 creator A5042823471 @default.
• W2053156659 creator A5046998280 @default.
• W2053156659 creator A5057037633 @default.
• W2053156659 creator A5063861158 @default.
• W2053156659 creator A5077916444 @default.
• W2053156659 date "2005-10-26" @default.
• W2053156659 modified "2023-10-18" @default.
• W2053156659 title "Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers" @default.
• W2053156659 cites W1607366303 @default.
• W2053156659 cites W1740737174 @default.
• W2053156659 cites W182509504 @default.
• W2053156659 cites W1964445130 @default.
• W2053156659 cites W1964858684 @default.
• W2053156659 cites W1980931922 @default.
• W2053156659 cites W1981315914 @default.
• W2053156659 cites W1983792141 @default.
• W2053156659 cites W1984153456 @default.
• W2053156659 cites W1990032829 @default.
• W2053156659 cites W1993491606 @default.
• W2053156659 cites W1994843266 @default.
• W2053156659 cites W2001957282 @default.
• W2053156659 cites W2002570890 @default.
• W2053156659 cites W2006763168 @default.
• W2053156659 cites W2014303129 @default.
• W2053156659 cites W2015824766 @default.
• W2053156659 cites W2016055442 @default.
• W2053156659 cites W2018375532 @default.
• W2053156659 cites W2037859708 @default.
• W2053156659 cites W2041109673 @default.
• W2053156659 cites W2041373340 @default.
• W2053156659 cites W2045681528 @default.
• W2053156659 cites W2055184276 @default.
• W2053156659 cites W2058680827 @default.
• W2053156659 cites W2063706304 @default.
• W2053156659 cites W2080913348 @default.
• W2053156659 cites W2082466191 @default.
• W2053156659 cites W2086232140 @default.
• W2053156659 cites W2086825126 @default.
• W2053156659 cites W2087329787 @default.
• W2053156659 cites W2093397667 @default.
• W2053156659 cites W2160559003 @default.
• W2053156659 doi "https://doi.org/10.1002/ijc.21292" @default.
• W2053156659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16003723" @default.
• W2053156659 hasPublicationYear "2005" @default.
• W2053156659 type Work @default.
• W2053156659 sameAs 2053156659 @default.
• W2053156659 citedByCount "24" @default.
• W2053156659 countsByYear W20531566592012 @default.
• W2053156659 countsByYear W20531566592013 @default.
• W2053156659 countsByYear W20531566592014 @default.
• W2053156659 countsByYear W20531566592016 @default.
• W2053156659 countsByYear W20531566592018 @default.
• W2053156659 countsByYear W20531566592019 @default.
• W2053156659 countsByYear W20531566592020 @default.
• W2053156659 countsByYear W20531566592021 @default.
• W2053156659 countsByYear W20531566592023 @default.
• W2053156659 crossrefType "journal-article" @default.
• W2053156659 hasAuthorship W2053156659A5008707617 @default.
• W2053156659 hasAuthorship W2053156659A5013036085 @default.
• W2053156659 hasAuthorship W2053156659A5018745405 @default.
• W2053156659 hasAuthorship W2053156659A5020268469 @default.
• W2053156659 hasAuthorship W2053156659A5042823471 @default.
• W2053156659 hasAuthorship W2053156659A5046998280 @default.
• W2053156659 hasAuthorship W2053156659A5057037633 @default.
• W2053156659 hasAuthorship W2053156659A5063861158 @default.
• W2053156659 hasAuthorship W2053156659A5077916444 @default.
• W2053156659 hasBestOaLocation W20531566591 @default.
• W2053156659 hasConcept C118303440 @default.
• W2053156659 hasConcept C121608353 @default.
• W2053156659 hasConcept C126322002 @default.
• W2053156659 hasConcept C154317977 @default.
• W2053156659 hasConcept C170493617 @default.
• W2053156659 hasConcept C185592680 @default.
• W2053156659 hasConcept C190283241 @default.
• W2053156659 hasConcept C202751555 @default.
• W2053156659 hasConcept C2776235491 @default.
• W2053156659 hasConcept C2776694085 @default.
• W2053156659 hasConcept C2776998989 @default.
• W2053156659 hasConcept C2778448772 @default.
• W2053156659 hasConcept C2779707156 @default.
• W2053156659 hasConcept C2780192828 @default.
• W2053156659 hasConcept C2781303535 @default.
• W2053156659 hasConcept C502942594 @default.
• W2053156659 hasConcept C55493867 @default.
• W2053156659 hasConcept C71924100 @default.
• W2053156659 hasConcept C98274493 @default.
• W2053156659 hasConceptScore W2053156659C118303440 @default.
• W2053156659 hasConceptScore W2053156659C121608353 @default.
• W2053156659 hasConceptScore W2053156659C126322002 @default.
• W2053156659 hasConceptScore W2053156659C154317977 @default.
• W2053156659 hasConceptScore W2053156659C170493617 @default.
• W2053156659 hasConceptScore W2053156659C185592680 @default.

• next