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• W2053158156 abstract "The embryonic capsule, which covers the equine blastocyst after it loses its zona pellucida, is composed of mucin-like glycoproteins. In the present study, we investigated both macroscopic and molecular changes in the capsule during development. The weight of the capsule increased from day 11–12 of pregnancy and reached a maximum at about day 18, coinciding with the time during which the conceptus migrates extensively throughout the uterus. The sialic acid content of the capsule declined markedly from about day 16, the time of conceptus 'fixation' in the uterus, which suggests a unique developmentally regulated mechanism for the control of embryo mobility. These results lead us to propose that the capsule may have an anti-adhesion function in the developing conceptus, and that this effect could be regulated by the sugar side chains of the capsular glycoproteins. The glycosylation characteristics of the blastocyst coverings also underwent changes at about day 9 of pregnancy, which may be related to loss of the zona pellucida. An anti-capsule monoclonal antibody was raised and shown to recognize a tissue-specific antigen present only on the capsule and trophoblast. This antigen was present on the trophoblastic cells soon after the blastocyst is formed, reached a maximum concentration at about day 18, and was absent after day 22, coinciding with the disappearance of the capsule. Immunohistochemical studies indicate that the mucinlike capsular glycoproteins are secreted, at least in major part, by the trophoblast. The pattern of secretion of these glycoproteins and the coincidence of molecular changes with important events in early pregnancy strongly suggest that they play crucial roles in early embryonic development." @default.
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• W2053158156 date "1993-11-01" @default.
• W2053158156 modified "2023-09-30" @default.
• W2053158156 title "Developmentally regulated changes in the glycoproteins of the equine embryonic capsule" @default.
• W2053158156 doi "https://doi.org/10.1530/jrf.0.0990653" @default.
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