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• W2053175077 abstract "To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata (C. odorata).The compounds isolated from the aerial parts of C. odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.Six fatty acids (S)-coriolic acid (1), (S)-coriolic acid methyl ester (2), (S)-15,16-didehydrocoriolic acid (3), (S)-15,16-didehydrocoriolic acid methyl ester (4), linoleamide (5) and linolenamide (6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition. Compound 2 was the most active with the IC(50) values of 5.22 and 5.73 μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.The fatty acid components in C. odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care." @default.
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• W2053175077 date "2011-10-01" @default.
• W2053175077 modified "2023-09-26" @default.
• W2053175077 title "Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata" @default.
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• W2053175077 doi "https://doi.org/10.1016/s1995-7645(11)60189-2" @default.
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