FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053191506> ?p ?o ?g. }

• W2053191506 endingPage "1167" @default.
• W2053191506 startingPage "1161" @default.
• W2053191506 abstract "Estrogens or antiestrogens are currently used by millions of women, but the interaction of these hormonal agents with brain estrogen receptors (ER) in vivo has not been characterized to date. Our goal was to assess, in vivo, the extent and regional distribution of brain ER occupancy in rats chronically exposed to 17beta-estradiol (E(2)) or tamoxifen (TAM). For that purpose, female ovariectomized Sprague-Dawley rats were implanted with subcutaneous pellets containing either placebo (OVX), E(2), or TAM for 3 weeks. ER occupancy in grossly dissected regions was quantified with 16alpha-[(18)F]fluoroestradiol ([(18)F]FES). Both E(2) and TAM produced significant decreases in radioligand uptake in the brain although the effect of E(2) was larger and more widespread than the effect of TAM. Detailed regional analysis of the interaction was then undertaken using a radioiodinated ligand, 11beta-methoxy-16alpha-[(125)I]iodo-estradiol ([(125)I]MIE(2)), and quantitative ex vivo autoradiography. E(2) treatment resulted in near-complete (86.6 +/- 17.5%) inhibition of radioligand accumulation throughout the brain, while ER occupancy in the TAM group showed a marked regional distribution such that percentage inhibition ranged from 40.5 +/- 15.6 in the ventrolateral part of the ventromedial hypothalamic nucleus to 84.6 +/- 4.5 in the cortical amygdala. These results show that exposure to pharmacologically relevant levels of TAM produces a variable, region-specific pattern of brain ER occupancy, which may be influenced by the regional proportion of ER receptor subtypes. These findings may partially explain the highly variable and region-specific effects observed in neurochemical, metabolic, and functional studies of the effects of TAM in the brain of experimental animals as well as human subjects." @default.
• W2053191506 created "2016-06-24" @default.
• W2053191506 creator A5027999733 @default.
• W2053191506 creator A5052478129 @default.
• W2053191506 creator A5062638994 @default.
• W2053191506 creator A5068943360 @default.
• W2053191506 date "2004-11-01" @default.
• W2053191506 modified "2023-10-02" @default.
• W2053191506 title "In vivo occupancy of female rat brain estrogen receptors by 17β-estradiol and tamoxifen" @default.
• W2053191506 cites W1488284274 @default.
• W2053191506 cites W1795513906 @default.
• W2053191506 cites W1914841629 @default.
• W2053191506 cites W1937097615 @default.
• W2053191506 cites W1954468845 @default.
• W2053191506 cites W1975412200 @default.
• W2053191506 cites W1984305000 @default.
• W2053191506 cites W1989962022 @default.
• W2053191506 cites W1993709026 @default.
• W2053191506 cites W2004641165 @default.
• W2053191506 cites W2006346377 @default.
• W2053191506 cites W2007980908 @default.
• W2053191506 cites W2012549407 @default.
• W2053191506 cites W2013856449 @default.
• W2053191506 cites W2015512743 @default.
• W2053191506 cites W2021284505 @default.
• W2053191506 cites W2026463041 @default.
• W2053191506 cites W2027061276 @default.
• W2053191506 cites W2028266700 @default.
• W2053191506 cites W2029193046 @default.
• W2053191506 cites W2036081220 @default.
• W2053191506 cites W2037225207 @default.
• W2053191506 cites W2038127485 @default.
• W2053191506 cites W2047968184 @default.
• W2053191506 cites W2049714897 @default.
• W2053191506 cites W2050107022 @default.
• W2053191506 cites W2054074894 @default.
• W2053191506 cites W2063184348 @default.
• W2053191506 cites W2068076267 @default.
• W2053191506 cites W2073353512 @default.
• W2053191506 cites W2078991266 @default.
• W2053191506 cites W2080987913 @default.
• W2053191506 cites W2083183508 @default.
• W2053191506 cites W2093702432 @default.
• W2053191506 cites W2098010773 @default.
• W2053191506 cites W2102870106 @default.
• W2053191506 cites W2126190154 @default.
• W2053191506 cites W2131677965 @default.
• W2053191506 cites W2137775562 @default.
• W2053191506 cites W2145865543 @default.
• W2053191506 cites W2323085480 @default.
• W2053191506 cites W2413918236 @default.
• W2053191506 cites W4238993662 @default.
• W2053191506 cites W4240866307 @default.
• W2053191506 cites W4247989981 @default.
• W2053191506 cites W4254096897 @default.
• W2053191506 doi "https://doi.org/10.1016/j.neuroimage.2004.07.036" @default.
• W2053191506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15528115" @default.
• W2053191506 hasPublicationYear "2004" @default.
• W2053191506 type Work @default.
• W2053191506 sameAs 2053191506 @default.
• W2053191506 citedByCount "17" @default.
• W2053191506 countsByYear W20531915062014 @default.
• W2053191506 countsByYear W20531915062016 @default.
• W2053191506 countsByYear W20531915062017 @default.
• W2053191506 countsByYear W20531915062018 @default.
• W2053191506 countsByYear W20531915062020 @default.
• W2053191506 countsByYear W20531915062022 @default.
• W2053191506 countsByYear W20531915062023 @default.
• W2053191506 crossrefType "journal-article" @default.
• W2053191506 hasAuthorship W2053191506A5027999733 @default.
• W2053191506 hasAuthorship W2053191506A5052478129 @default.
• W2053191506 hasAuthorship W2053191506A5062638994 @default.
• W2053191506 hasAuthorship W2053191506A5068943360 @default.
• W2053191506 hasConcept C121608353 @default.
• W2053191506 hasConcept C126322002 @default.
• W2053191506 hasConcept C134018914 @default.
• W2053191506 hasConcept C150903083 @default.
• W2053191506 hasConcept C170493617 @default.
• W2053191506 hasConcept C185592680 @default.
• W2053191506 hasConcept C207001950 @default.
• W2053191506 hasConcept C26291073 @default.
• W2053191506 hasConcept C2777164284 @default.
• W2053191506 hasConcept C2777176818 @default.
• W2053191506 hasConcept C530470458 @default.
• W2053191506 hasConcept C67847695 @default.
• W2053191506 hasConcept C71924100 @default.
• W2053191506 hasConcept C8264082 @default.
• W2053191506 hasConcept C84606932 @default.
• W2053191506 hasConcept C86803240 @default.
• W2053191506 hasConceptScore W2053191506C121608353 @default.
• W2053191506 hasConceptScore W2053191506C126322002 @default.
• W2053191506 hasConceptScore W2053191506C134018914 @default.
• W2053191506 hasConceptScore W2053191506C150903083 @default.
• W2053191506 hasConceptScore W2053191506C170493617 @default.
• W2053191506 hasConceptScore W2053191506C185592680 @default.
• W2053191506 hasConceptScore W2053191506C207001950 @default.
• W2053191506 hasConceptScore W2053191506C26291073 @default.
• W2053191506 hasConceptScore W2053191506C2777164284 @default.

• next