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- W2053196246 abstract "A lysosomal cathepsin D (EC 3.4.23.5) was purified to homogeneity from the soft tissues of the fresh water mussel (Lamellidens corrianus) by pepstatin A affinity chromatography. The purified enzyme is a glycoprotein and migrates as a single protein species in native PAGE and shows a single band in SDS-PAGE corresponding to a molecular mass of ~43 kDa. Under both these conditions cathepsin D hydrolyzes hemoglobin as shown by zymogram analysis. The purified enzyme cross-reacts with an antiserum to purified starfish (Asterias rubens) cathepsin D. Additionally, the enzyme was recognized by the starfish lysosomal enzyme targeting receptors (mannose 6-phosphate receptors: MPR 300 and 46) in ligand blot analysis. The KM value of the purified enzyme with hemoglobin is 1.5mM. pH and temperature optimum for the enzyme are 3.5 and 60 °C respectively." @default.
- W2053196246 created "2016-06-24" @default.
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- W2053196246 date "2014-03-01" @default.
- W2053196246 modified "2023-09-26" @default.
- W2053196246 title "Biochemical characterization of cathepsin D from the mussel Lamellidens corrianus" @default.
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- W2053196246 doi "https://doi.org/10.1016/j.cbpb.2013.12.003" @default.
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