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• W2053201770 abstract "In contrast to the partition coefficient octanol/water the molecular size of penetrating drugs has a noticeable influence on the permeability of the human nail plate and a keratin membrane from bovine hooves. The relationship between permeability and molecular weight is founded on well-established theories. The correlation between the permeability of the nail plate and that of the hoof membrane allows a prediction of the nail permeability after determination of the drug penetration through the hoof membrane. The maximum flux of ten antimycotics (amorolfine, bifonazole, ciclopirox, clotrimazole, econazole, griseofulvin, ketoconazole, naftifine, nystatin and tolnaftate) through the nail plate was predicted on the basis of their penetration rates through the hoof membrane and their water solubilities. An efficacy coefficient against onychomycoses was calculated from the maximum flux and the minimum inhibitory concentration. Accordingly, amorolfine, ciclopirox, econazole and naftifine are expected to be especially effective against dermatophytes, whereas in the case of an infection with yeasts only, amorolfine and ciclopirox are promising." @default.
• W2053201770 created "2016-06-24" @default.
• W2053201770 creator A5005122196 @default.
• W2053201770 creator A5066911011 @default.
• W2053201770 date "1997-09-01" @default.
• W2053201770 modified "2023-10-16" @default.
• W2053201770 title "In-vitro Permeability of the Human Nail and of a Keratin Membrane from Bovine Hooves: Prediction of the Penetration Rate of Antimycotics through the Nail Plate and their Efficacy" @default.
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• W2053201770 doi "https://doi.org/10.1111/j.2042-7158.1997.tb06127.x" @default.
• W2053201770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9306253" @default.
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