FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053202457> ?p ?o ?g. }

• W2053202457 endingPage "879" @default.
• W2053202457 startingPage "873" @default.
• W2053202457 abstract "We have previously described a significant increase in cellular DNA and nuclear T3 receptor concentration in S phase cultures of GC cells, a rat pituitary cell line that produces GH. We have now measured GH production and some aspects of GH regulation in asynchronous cells and in cultures that were synchronized in early S phase by 25-h treatment with 2 mM thymidine (dT). Cellular DNA and both cellular and medium GH increased significantly at the end of dT treatment and for 3–6 h after removal of dT (S phase). Pulse-labeling experiments with [3H]leucine followed by specific immunoprecipitation of rat GH suggested that an S phase-associated 87% increase in GH could be attributed predominantly to a 101% increase in the GH synthesis rate. The relative GH synthesis rate (GH synthesis -rtotal protein synthesis) increased from 0.85% to 1.70% during the S phase. Since cortisol (115 nM) augmented GH production in both asynchronous and S phase cultures, studies of glucocorticoid receptor concentration were also carried out. In comparison with asynchronous cultures, a significant increase in glucocorticoid receptor was identified in the nuclear fraction but not in the cytosol of cultures synchronized in the S phase. Studies with cells grown in media which were selectively depleted or repleted with T3 and/or cortisol and experiments with the glucocorticoid antagonist 17α-methyltestosterone suggested that T3 was primarily responsible for augmented GH during the S phase and that cortisol modulated the amplitude of this response. Our studies suggest that increases in DNA, nuclear receptors for T3 and glucocorticoids, and GH synthesis occur in GC cell cultures synchronized in the S phase. We conclude that the GH production rate observed in asynchronous cultures may be an integrated value for all phases of the cell cycle, each of which may have a distinctive rate of hormone synthesis. (Endocrinology114: 873, 1984)" @default.
• W2053202457 created "2016-06-24" @default.
• W2053202457 creator A5014754559 @default.
• W2053202457 creator A5058865612 @default.
• W2053202457 date "1984-03-01" @default.
• W2053202457 modified "2023-10-15" @default.
• W2053202457 title "Increase in Nuclear Thyroid and Glucocorticoid Receptors and Growth Hormone Production during the Deoxyribonucleic Acid Synthesis Phase of the Cell Growth Cycle^*" @default.
• W2053202457 cites W1541647579 @default.
• W2053202457 cites W1545957512 @default.
• W2053202457 cites W1552179324 @default.
• W2053202457 cites W1568015334 @default.
• W2053202457 cites W1569915920 @default.
• W2053202457 cites W1578995842 @default.
• W2053202457 cites W1588885776 @default.
• W2053202457 cites W1604887498 @default.
• W2053202457 cites W1775749144 @default.
• W2053202457 cites W1946417846 @default.
• W2053202457 cites W1970895519 @default.
• W2053202457 cites W1974313609 @default.
• W2053202457 cites W1979544459 @default.
• W2053202457 cites W1985985343 @default.
• W2053202457 cites W1989408766 @default.
• W2053202457 cites W1992032967 @default.
• W2053202457 cites W1994027777 @default.
• W2053202457 cites W2012234095 @default.
• W2053202457 cites W2018287603 @default.
• W2053202457 cites W2025471166 @default.
• W2053202457 cites W2046571799 @default.
• W2053202457 cites W2051590029 @default.
• W2053202457 cites W2053173024 @default.
• W2053202457 cites W2054496266 @default.
• W2053202457 cites W2060364237 @default.
• W2053202457 cites W2064952052 @default.
• W2053202457 cites W2076092489 @default.
• W2053202457 cites W2092727047 @default.
• W2053202457 cites W2107636336 @default.
• W2053202457 cites W2131498622 @default.
• W2053202457 cites W2151772354 @default.
• W2053202457 cites W2154742909 @default.
• W2053202457 cites W2224450636 @default.
• W2053202457 cites W2399889170 @default.
• W2053202457 cites W2419377870 @default.
• W2053202457 cites W2464826302 @default.
• W2053202457 doi "https://doi.org/10.1210/endo-114-3-873" @default.
• W2053202457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6321144" @default.
• W2053202457 hasPublicationYear "1984" @default.
• W2053202457 type Work @default.
• W2053202457 sameAs 2053202457 @default.
• W2053202457 citedByCount "16" @default.
• W2053202457 crossrefType "journal-article" @default.
• W2053202457 hasAuthorship W2053202457A5014754559 @default.
• W2053202457 hasAuthorship W2053202457A5058865612 @default.
• W2053202457 hasBestOaLocation W20532024571 @default.
• W2053202457 hasConcept C104317684 @default.
• W2053202457 hasConcept C126322002 @default.
• W2053202457 hasConcept C134018914 @default.
• W2053202457 hasConcept C170493617 @default.
• W2053202457 hasConcept C2777108182 @default.
• W2053202457 hasConcept C2780004078 @default.
• W2053202457 hasConcept C2780841215 @default.
• W2053202457 hasConcept C54355233 @default.
• W2053202457 hasConcept C552990157 @default.
• W2053202457 hasConcept C55493867 @default.
• W2053202457 hasConcept C59493245 @default.
• W2053202457 hasConcept C62112901 @default.
• W2053202457 hasConcept C63932345 @default.
• W2053202457 hasConcept C64241487 @default.
• W2053202457 hasConcept C71924100 @default.
• W2053202457 hasConcept C81885089 @default.
• W2053202457 hasConcept C86339819 @default.
• W2053202457 hasConcept C86803240 @default.
• W2053202457 hasConceptScore W2053202457C104317684 @default.
• W2053202457 hasConceptScore W2053202457C126322002 @default.
• W2053202457 hasConceptScore W2053202457C134018914 @default.
• W2053202457 hasConceptScore W2053202457C170493617 @default.
• W2053202457 hasConceptScore W2053202457C2777108182 @default.
• W2053202457 hasConceptScore W2053202457C2780004078 @default.
• W2053202457 hasConceptScore W2053202457C2780841215 @default.
• W2053202457 hasConceptScore W2053202457C54355233 @default.
• W2053202457 hasConceptScore W2053202457C552990157 @default.
• W2053202457 hasConceptScore W2053202457C55493867 @default.
• W2053202457 hasConceptScore W2053202457C59493245 @default.
• W2053202457 hasConceptScore W2053202457C62112901 @default.
• W2053202457 hasConceptScore W2053202457C63932345 @default.
• W2053202457 hasConceptScore W2053202457C64241487 @default.
• W2053202457 hasConceptScore W2053202457C71924100 @default.
• W2053202457 hasConceptScore W2053202457C81885089 @default.
• W2053202457 hasConceptScore W2053202457C86339819 @default.
• W2053202457 hasConceptScore W2053202457C86803240 @default.
• W2053202457 hasIssue "3" @default.
• W2053202457 hasLocation W20532024571 @default.
• W2053202457 hasLocation W20532024572 @default.
• W2053202457 hasOpenAccess W2053202457 @default.
• W2053202457 hasPrimaryLocation W20532024571 @default.
• W2053202457 hasRelatedWork W1567962285 @default.
• W2053202457 hasRelatedWork W1812173233 @default.
• W2053202457 hasRelatedWork W1988490778 @default.
• W2053202457 hasRelatedWork W2037830123 @default.

• next