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- W2053202566 abstract "A cDNA of 1650 base pairs was isolated by screening an HL-60 granulocyte library with an N-formyl peptide receptor (NFPR) cDNA probe under low stringency conditions. The cDNA encodes a protein of 351 amino acids tentatively named FPR2, with a calculated molecular weight of 39 kDa. Sequence analysis revealed that FPR2 is 69% identical in sequence to the human NFPR and shares extensive homology to several other chemoattractant receptors. FPR2 expressed in transfected cells mediated formyl peptide-stimulated calcium mobilization at micromolar concentrations of ligand. FPR2 messenger is detected in granulocytic HL-60 cells, but not in undifferentiated HL-60 cells. These findings suggest that FPR2 is a novel receptor for formyl peptide ligand and a new member of the chemoattractant receptor gene family." @default.
- W2053202566 created "2016-06-24" @default.
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- W2053202566 date "1992-04-01" @default.
- W2053202566 modified "2023-09-24" @default.
- W2053202566 title "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor" @default.
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- W2053202566 doi "https://doi.org/10.1016/0006-291x(92)90629-y" @default.
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