FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053202919> ?p ?o ?g. }

• W2053202919 abstract "Objective: Weight loss is a near societal obsession and many diet programs use significant calorie restriction (CR) including fasting/short term starvation to generate rapid effects. Fasting is also a well-recognized cause of immunosuppression especially within the innate immune system. In this study, we sought to determine if the IL-1 arm of the neuroimmune system was down-regulated by a 24 hr fast and how fasting might generate this effect. Design: Mice were allowed ad libitum access to food or had food withheld for 24 hrs. Expression of the endogenous IL-1 antagonists IL-1 receptor type 2 (IL-1R2) and IL-1 receptor antagonist (IL-1RA) were determined as were sickness behaviors before and after IL-1 administration.Results: Fasting markedly increased gene expression of IL-1R2 (83-fold in adipose tissue, 9.5-fold in liver) and IL-1RA (68-fold in liver). Fasted mice were protected from IL-1-induced weight loss, hypoglycemia, loss of locomotor and social anxiety. These protections were coupled to a large positive interaction of fasting and IL-1 on IL-1R2 gene expression in adipose tissue and liver (2.6-fold and 1.6-fold, respectively). Fasting not only increased IL-1RA and IL-1R2 protein 2.5-fold and 3.2-fold, respectively, in liver; but also increased IL-1R2 1.8-fold in adipose tissue. Fasting, in turn, triggered a 2.4-fold increase in plasma free-fatty acids (FFAs) and a 2.1-fold increase in plasma corticosterone. Inhibition, of glucocorticoid action with mifepristone did not impact fasting-dependent IL-1R2 or IL-1RA gene expression. Administration of the FFA, palmitate, to mice increased liver IL-1R2 and IL-1RA gene expression by 14-fold and 11-fold, respectively. Conclusion: These findings indicate that fasting augments expression of endogenous IL-1 antagonists inducing IL-1 resistance. Fasting-induced increases in plasma FFAs appears to be a signal that drives immunosuppression during fasting/short term starvation." @default.
• W2053202919 created "2016-06-24" @default.
• W2053202919 creator A5021875756 @default.
• W2053202919 creator A5026941724 @default.
• W2053202919 creator A5028372081 @default.
• W2053202919 creator A5068328297 @default.
• W2053202919 creator A5079850324 @default.
• W2053202919 creator A5089408410 @default.
• W2053202919 date "2014-07-09" @default.
• W2053202919 modified "2023-10-15" @default.
• W2053202919 title "Fasting Induces IL-1 Resistance and Free-Fatty Acid-Mediated Up-Regulation of IL-1R2 and IL-1RA" @default.
• W2053202919 cites W1896791850 @default.
• W2053202919 cites W1965263019 @default.
• W2053202919 cites W1970528904 @default.
• W2053202919 cites W1979146329 @default.
• W2053202919 cites W1980132403 @default.
• W2053202919 cites W1981118821 @default.
• W2053202919 cites W1986272286 @default.
• W2053202919 cites W1989426622 @default.
• W2053202919 cites W1989825818 @default.
• W2053202919 cites W1991652381 @default.
• W2053202919 cites W1998522372 @default.
• W2053202919 cites W2001652786 @default.
• W2053202919 cites W2003282625 @default.
• W2053202919 cites W2004070779 @default.
• W2053202919 cites W2008687046 @default.
• W2053202919 cites W2012968633 @default.
• W2053202919 cites W2020762391 @default.
• W2053202919 cites W2023024827 @default.
• W2053202919 cites W2031721046 @default.
• W2053202919 cites W2037084553 @default.
• W2053202919 cites W2038182824 @default.
• W2053202919 cites W2040942138 @default.
• W2053202919 cites W2043018600 @default.
• W2053202919 cites W2050209877 @default.
• W2053202919 cites W2051879843 @default.
• W2053202919 cites W2053212420 @default.
• W2053202919 cites W2054879507 @default.
• W2053202919 cites W2057521072 @default.
• W2053202919 cites W2059580306 @default.
• W2053202919 cites W2062487385 @default.
• W2053202919 cites W2063508561 @default.
• W2053202919 cites W2077629812 @default.
• W2053202919 cites W2083666530 @default.
• W2053202919 cites W2085764996 @default.
• W2053202919 cites W2092165644 @default.
• W2053202919 cites W2093957918 @default.
• W2053202919 cites W2096301780 @default.
• W2053202919 cites W2098416076 @default.
• W2053202919 cites W2099555137 @default.
• W2053202919 cites W2100978187 @default.
• W2053202919 cites W2102964449 @default.
• W2053202919 cites W2103071544 @default.
• W2053202919 cites W2103650651 @default.
• W2053202919 cites W2105825037 @default.
• W2053202919 cites W2121795979 @default.
• W2053202919 cites W2125866626 @default.
• W2053202919 cites W2126795224 @default.
• W2053202919 cites W2130460031 @default.
• W2053202919 cites W2130495917 @default.
• W2053202919 cites W2132682806 @default.
• W2053202919 cites W2144330335 @default.
• W2053202919 cites W2150606130 @default.
• W2053202919 cites W2150702412 @default.
• W2053202919 cites W2158476520 @default.
• W2053202919 cites W2163269381 @default.
• W2053202919 cites W2187193114 @default.
• W2053202919 cites W2418400864 @default.
• W2053202919 doi "https://doi.org/10.3389/fimmu.2014.00315" @default.
• W2053202919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4089087" @default.
• W2053202919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25071776" @default.
• W2053202919 hasPublicationYear "2014" @default.
• W2053202919 type Work @default.
• W2053202919 sameAs 2053202919 @default.
• W2053202919 citedByCount "12" @default.
• W2053202919 countsByYear W20532029192015 @default.
• W2053202919 countsByYear W20532029192016 @default.
• W2053202919 countsByYear W20532029192017 @default.
• W2053202919 countsByYear W20532029192018 @default.
• W2053202919 countsByYear W20532029192019 @default.
• W2053202919 countsByYear W20532029192020 @default.
• W2053202919 countsByYear W20532029192023 @default.
• W2053202919 crossrefType "journal-article" @default.
• W2053202919 hasAuthorship W2053202919A5021875756 @default.
• W2053202919 hasAuthorship W2053202919A5026941724 @default.
• W2053202919 hasAuthorship W2053202919A5028372081 @default.
• W2053202919 hasAuthorship W2053202919A5068328297 @default.
• W2053202919 hasAuthorship W2053202919A5079850324 @default.
• W2053202919 hasAuthorship W2053202919A5089408410 @default.
• W2053202919 hasBestOaLocation W20532029191 @default.
• W2053202919 hasConcept C126322002 @default.
• W2053202919 hasConcept C134018914 @default.
• W2053202919 hasConcept C149984733 @default.
• W2053202919 hasConcept C151955695 @default.
• W2053202919 hasConcept C170493617 @default.
• W2053202919 hasConcept C171089720 @default.
• W2053202919 hasConcept C203014093 @default.
• W2053202919 hasConcept C2780352252 @default.
• W2053202919 hasConcept C511355011 @default.
• W2053202919 hasConcept C544821477 @default.

• next