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• W2053202964 startingPage "7192" @default.
• W2053202964 abstract "Lineage-tracing experiments have shown that some premigratory neural crest cells generate both sensory (S) and autonomic (A) derivatives, whereas others generate only S derivatives. Whether this lineage heterogeneity reflects random variation in a homogeneous population or an early sensory specification of some premigratory crest cells has not been clear. Using Cre recombinase-based fate mapping, we show that GDF7, which is exclusively expressed in the roof plate, marks neural crest cells with a 10-fold higher bias to the sensory lineage than those marked (at the same stage of development) by an inducible Wnt1-Cre, which is expressed more broadly in the dorsal neural tube. In vitro , GDF7 has potent sensory neuron-inducing activity. These data suggest that some premigratory crest cells are deterministically restricted to the S lineage and implicate GDF7 itself in this restriction process." @default.
• W2053202964 created "2016-06-24" @default.
• W2053202964 creator A5015201066 @default.
• W2053202964 creator A5030428967 @default.
• W2053202964 creator A5073992167 @default.
• W2053202964 date "2005-05-09" @default.
• W2053202964 modified "2023-09-23" @default.
• W2053202964 title "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7" @default.
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• W2053202964 doi "https://doi.org/10.1073/pnas.0502581102" @default.
• W2053202964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1091754" @default.
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