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- W2053204016 abstract "Newborn rats were orally dosed at 2 or 24 hr of age with 1 μCi of 115mCd and killed at intervals between 1 and 21 days after dosing. Cadmium absorption (systemic absorption) was about six times greater in 2-hr-old pups as compared with 1-day-old pups, but the rate of absorption after Day 1 was similar in both age groups. Post weanling rats dosed at 6 weeks of age absorbed 0.5% of the Cd dose, whereas rats dosed at 2 and 24 hr of age absorbed approximately 12 and 5% of the dose, respectively. Cadmium was tenaciously retained in the gastrointestinal tract of newborn rats, with over 60% of the Cd dose remaining in the gastrointestinal tract 15 days after dosing. Autoradiographs showed considerable amounts of radioactivity not only in the intestinal surface epithelium and brush borders, but also in the crypts, lamina propia, and muscular layer. Because of the greater absorption and the prolonged intestinal retention of Cd in the newborn rat and the long biological half-life of Cd in the body, Cd exposure in infancy could result in greater lifetime Cd accumulation. The prolonged intestinal retention of Cd may have significant implications on the interpretation of short-term balance studies of metals." @default.
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- W2053204016 date "1977-08-01" @default.
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- W2053204016 title "Intestinal absorption and retention of cadmium in neonatal rat*1" @default.
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- W2053204016 doi "https://doi.org/10.1016/0041-008x(77)90043-6" @default.
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