FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053204172> ?p ?o ?g. }

• W2053204172 abstract "1. Ventricular hypertrophy is characterized by stimulation of ventricular synthesis of atrial natriuretic peptide (ANP). To examine the role of ventricular ANP levels in the secretion of ANP into the circulation, atrial and ventricular levels of immunoreactive-ANP (IR-ANP) as well as ANP messenger RNA (mRNA), and the release of IR-ANP from isolated perfused hearts, both before and after atrialectomy, were measured simultaneously in control and minoxidil-treated Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. 2. IR-ANP levels in the ventricles of untreated, 12 month-old SHR with severe ventricular hypertrophy were increased when compared to age-matched WKY rats. Minoxidil treatment for 8 weeks in both strains resulted in a decrease in mean arterial pressure and increases in ventricular weight to body weight ratios, plasma IR-ANP concentrations (in WKY from 133 +/- 20 to 281 +/- 34 pg ml-1, P less than 0.01; in SHR from 184 +/- 38 to 339 +/- 61 pg ml-1, P less than 0.05), and in ventricular IR-ANP contents (in WKY: 53%; in SHR: 41%). A highly significant correlation was found between ventricular IR-ANP content and ventricular weight to body weight ratio (r = 0.59, P less than 0.001, n = 26). 3. When studied in vitro, in isolated perfused heart preparations, the hypertrophied ventricular tissue after atrialectomy secreted more ANP into the perfusate than ventricles of the control hearts; ventricles contributed 28%, 22%, 18% and 15% of the total ANP release to perfusate in the minoxidil-treated SHR, control SHR, minoxidil-treated WKY and control WKY, respectively. A significant correlation was found between the IR-ANP release from ventricles and ventricular weight to body weight ratio (r = 0.56, P < 0.01, n = 24). 4. These studies demonstrate that the ventricles contribute substantially to the circulating level of ANP, and that the amount released depends on the degree of ventricular hypertrophy." @default.
• W2053204172 created "2016-06-24" @default.
• W2053204172 creator A5007015109 @default.
• W2053204172 creator A5020102435 @default.
• W2053204172 creator A5052466726 @default.
• W2053204172 creator A5069650608 @default.
• W2053204172 date "1990-04-01" @default.
• W2053204172 modified "2023-10-17" @default.
• W2053204172 title "Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy" @default.
• W2053204172 cites W1980754877 @default.
• W2053204172 cites W1988628327 @default.
• W2053204172 cites W1989161728 @default.
• W2053204172 cites W1997202516 @default.
• W2053204172 cites W2003845465 @default.
• W2053204172 cites W2004564179 @default.
• W2053204172 cites W2005010203 @default.
• W2053204172 cites W2005625712 @default.
• W2053204172 cites W2012041356 @default.
• W2053204172 cites W2014371208 @default.
• W2053204172 cites W2022883773 @default.
• W2053204172 cites W2023379265 @default.
• W2053204172 cites W2023644858 @default.
• W2053204172 cites W2030830444 @default.
• W2053204172 cites W2047025106 @default.
• W2053204172 cites W2051163001 @default.
• W2053204172 cites W2051743630 @default.
• W2053204172 cites W2054745101 @default.
• W2053204172 cites W2055480062 @default.
• W2053204172 cites W2059946639 @default.
• W2053204172 cites W2061430929 @default.
• W2053204172 cites W2071443658 @default.
• W2053204172 cites W2080068550 @default.
• W2053204172 cites W2081834834 @default.
• W2053204172 cites W2085864418 @default.
• W2053204172 cites W2088986997 @default.
• W2053204172 cites W2090720549 @default.
• W2053204172 cites W2103897701 @default.
• W2053204172 cites W2105046056 @default.
• W2053204172 cites W2127479585 @default.
• W2053204172 cites W2132161051 @default.
• W2053204172 cites W2135808631 @default.
• W2053204172 cites W2161289635 @default.
• W2053204172 cites W2166079697 @default.
• W2053204172 cites W2211832838 @default.
• W2053204172 cites W2414358906 @default.
• W2053204172 cites W2469563931 @default.
• W2053204172 doi "https://doi.org/10.1111/j.1476-5381.1990.tb12992.x" @default.
• W2053204172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917530" @default.
• W2053204172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2141796" @default.
• W2053204172 hasPublicationYear "1990" @default.
• W2053204172 type Work @default.
• W2053204172 sameAs 2053204172 @default.
• W2053204172 citedByCount "10" @default.
• W2053204172 countsByYear W20532041722020 @default.
• W2053204172 crossrefType "journal-article" @default.
• W2053204172 hasAuthorship W2053204172A5007015109 @default.
• W2053204172 hasAuthorship W2053204172A5020102435 @default.
• W2053204172 hasAuthorship W2053204172A5052466726 @default.
• W2053204172 hasAuthorship W2053204172A5069650608 @default.
• W2053204172 hasBestOaLocation W20532041721 @default.
• W2053204172 hasConcept C126322002 @default.
• W2053204172 hasConcept C134018914 @default.
• W2053204172 hasConcept C167414201 @default.
• W2053204172 hasConcept C185592680 @default.
• W2053204172 hasConcept C24998067 @default.
• W2053204172 hasConcept C2776002628 @default.
• W2053204172 hasConcept C2776835912 @default.
• W2053204172 hasConcept C2778069365 @default.
• W2053204172 hasConcept C2779711729 @default.
• W2053204172 hasConcept C71924100 @default.
• W2053204172 hasConcept C84393581 @default.
• W2053204172 hasConceptScore W2053204172C126322002 @default.
• W2053204172 hasConceptScore W2053204172C134018914 @default.
• W2053204172 hasConceptScore W2053204172C167414201 @default.
• W2053204172 hasConceptScore W2053204172C185592680 @default.
• W2053204172 hasConceptScore W2053204172C24998067 @default.
• W2053204172 hasConceptScore W2053204172C2776002628 @default.
• W2053204172 hasConceptScore W2053204172C2776835912 @default.
• W2053204172 hasConceptScore W2053204172C2778069365 @default.
• W2053204172 hasConceptScore W2053204172C2779711729 @default.
• W2053204172 hasConceptScore W2053204172C71924100 @default.
• W2053204172 hasConceptScore W2053204172C84393581 @default.
• W2053204172 hasLocation W20532041721 @default.
• W2053204172 hasLocation W20532041722 @default.
• W2053204172 hasLocation W20532041723 @default.
• W2053204172 hasLocation W20532041724 @default.
• W2053204172 hasOpenAccess W2053204172 @default.
• W2053204172 hasPrimaryLocation W20532041721 @default.
• W2053204172 hasRelatedWork W2009477922 @default.
• W2053204172 hasRelatedWork W2034129482 @default.
• W2053204172 hasRelatedWork W2053204172 @default.
• W2053204172 hasRelatedWork W2090720549 @default.
• W2053204172 hasRelatedWork W2141037139 @default.
• W2053204172 hasRelatedWork W2254355701 @default.
• W2053204172 hasRelatedWork W2358473075 @default.
• W2053204172 hasRelatedWork W2764849705 @default.
• W2053204172 hasRelatedWork W2773785061 @default.
• W2053204172 hasRelatedWork W3151621359 @default.
• W2053204172 isParatext "false" @default.
• W2053204172 isRetracted "false" @default.

• next