FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053218476> ?p ?o ?g. }

• W2053218476 endingPage "165" @default.
• W2053218476 startingPage "159" @default.
• W2053218476 abstract "BACKGROUND Although essential, androgens alone are not sufficient to induce normal growth and functionality of the prostate. Nonandrogenic hormones must also be involved in the proliferation of the prostate cancer cells which do not respond to antiandrogenic therapy and which thus become androgen-independent. Prolactin, but also growth hormone and luteinizing hormone, are potentially able to act on both normal and abnormal prostatic cells. METHODS In this review we summarize data from the literature concerning the physiological and pathological implications of prolactin, growth hormone, and luteinizing hormone on the prostate. RESULTS In rodent prostates, prolactin and growth hormone can induce a variety of effects independently of androgens (e.g., transactivation of certain genes, or synthesis of the major secretion products). Moreover, hyperprolactinemia is responsible for inflammation and dysplasia of the gland, while growth hormone promotes the development of prostate tumors in vivo in the mouse and rat. Growth hormone acts on the gland directly, through prostatic growth hormone receptors, and/or indirectly via the stimulation of insulin-like growth factor-I (IGF-I) synthesis in the liver. Luteinizing hormone receptor is expressed in rat and human prostates. Luteinizing hormone increases the amount of various transcripts in the rat prostate through an androgen-independent pathway. CONCLUSIONS Prolactin, growth hormone, and luteinizing hormone, alone or synergistically with androgens, play physiologically significant roles in the normal prostate. The involvement of these hormones in the development of benign prostatic hyperplasia and prostatic carcinoma is an issue that needs to be addressed. Prostate 38:159–165, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2053218476 created "2016-06-24" @default.
• W2053218476 creator A5005989819 @default.
• W2053218476 creator A5020766649 @default.
• W2053218476 creator A5037079541 @default.
• W2053218476 creator A5045933219 @default.
• W2053218476 creator A5052830196 @default.
• W2053218476 creator A5059609470 @default.
• W2053218476 creator A5077718869 @default.
• W2053218476 creator A5079512406 @default.
• W2053218476 date "1999-02-01" @default.
• W2053218476 modified "2023-10-12" @default.
• W2053218476 title "Effects of pituitary hormones on the prostate" @default.
• W2053218476 cites W1889623179 @default.
• W2053218476 cites W1964613293 @default.
• W2053218476 cites W1965445884 @default.
• W2053218476 cites W1966050646 @default.
• W2053218476 cites W1969806489 @default.
• W2053218476 cites W1974952102 @default.
• W2053218476 cites W1977341142 @default.
• W2053218476 cites W1980613758 @default.
• W2053218476 cites W1981030701 @default.
• W2053218476 cites W1982373040 @default.
• W2053218476 cites W1983026354 @default.
• W2053218476 cites W1985379220 @default.
• W2053218476 cites W1988349823 @default.
• W2053218476 cites W1990781244 @default.
• W2053218476 cites W1992804332 @default.
• W2053218476 cites W1997348862 @default.
• W2053218476 cites W2009332173 @default.
• W2053218476 cites W2010057554 @default.
• W2053218476 cites W2010186999 @default.
• W2053218476 cites W2012527285 @default.
• W2053218476 cites W2014310781 @default.
• W2053218476 cites W2020636054 @default.
• W2053218476 cites W2021572371 @default.
• W2053218476 cites W2023759516 @default.
• W2053218476 cites W2035844721 @default.
• W2053218476 cites W2037615247 @default.
• W2053218476 cites W2038162032 @default.
• W2053218476 cites W2041755720 @default.
• W2053218476 cites W2042127364 @default.
• W2053218476 cites W2052327442 @default.
• W2053218476 cites W2057130283 @default.
• W2053218476 cites W2059671369 @default.
• W2053218476 cites W2062926146 @default.
• W2053218476 cites W2068090379 @default.
• W2053218476 cites W2068577816 @default.
• W2053218476 cites W2070839157 @default.
• W2053218476 cites W2071932829 @default.
• W2053218476 cites W2076258952 @default.
• W2053218476 cites W2077914981 @default.
• W2053218476 cites W2078789577 @default.
• W2053218476 cites W2078889029 @default.
• W2053218476 cites W2080109865 @default.
• W2053218476 cites W2084281846 @default.
• W2053218476 cites W2084988392 @default.
• W2053218476 cites W2088371750 @default.
• W2053218476 cites W2090844907 @default.
• W2053218476 cites W2092391822 @default.
• W2053218476 cites W2093907828 @default.
• W2053218476 cites W2093909923 @default.
• W2053218476 cites W2110310047 @default.
• W2053218476 cites W2142029612 @default.
• W2053218476 cites W2147292969 @default.
• W2053218476 cites W2147666122 @default.
• W2053218476 cites W2165530215 @default.
• W2053218476 cites W2400312919 @default.
• W2053218476 cites W4553897 @default.
• W2053218476 cites W47465036 @default.
• W2053218476 doi "https://doi.org/10.1002/(sici)1097-0045(19990201)38:2<159::aid-pros10>3.0.co;2-5" @default.
• W2053218476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9973102" @default.
• W2053218476 hasPublicationYear "1999" @default.
• W2053218476 type Work @default.
• W2053218476 sameAs 2053218476 @default.
• W2053218476 citedByCount "77" @default.
• W2053218476 countsByYear W20532184762012 @default.
• W2053218476 countsByYear W20532184762013 @default.
• W2053218476 countsByYear W20532184762014 @default.
• W2053218476 countsByYear W20532184762016 @default.
• W2053218476 countsByYear W20532184762017 @default.
• W2053218476 countsByYear W20532184762020 @default.
• W2053218476 countsByYear W20532184762021 @default.
• W2053218476 crossrefType "journal-article" @default.
• W2053218476 hasAuthorship W2053218476A5005989819 @default.
• W2053218476 hasAuthorship W2053218476A5020766649 @default.
• W2053218476 hasAuthorship W2053218476A5037079541 @default.
• W2053218476 hasAuthorship W2053218476A5045933219 @default.
• W2053218476 hasAuthorship W2053218476A5052830196 @default.
• W2053218476 hasAuthorship W2053218476A5059609470 @default.
• W2053218476 hasAuthorship W2053218476A5077718869 @default.
• W2053218476 hasAuthorship W2053218476A5079512406 @default.
• W2053218476 hasConcept C121608353 @default.
• W2053218476 hasConcept C126322002 @default.
• W2053218476 hasConcept C134018914 @default.
• W2053218476 hasConcept C2776235491 @default.
• W2053218476 hasConcept C2777911890 @default.
• W2053218476 hasConcept C2778575703 @default.

• next