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- W2053226757 abstract "Primary hepatocellular carcinoma (HCC) is one of the most common solid malignancies [1]. Despite recent improvements in surveillance, diagnosis and clinical treatment strategies, HCC prognosis remains dismal. Patients often experience high metastasis or recurrence rates, and postoperative 5-year survival ranges from 17 % to 53 % [2]. To date, many studies have reported aberrant gene expression in HCC, but molecular factors identified as potential therapeutic targets remain limited. Therefore, it is a challenging task to identify relevant biomarkers or potential pharmacological targets in clinical practice. The high mobility group A2 (HMGA2; also called HMGI-C) protein, a member of the high mobility group AT-hook (HMGA) family, is a small non-histone chromosomal protein that has no intrinsic transcriptional activity, but can modulate transcription by binding to DNA and altering chromatin architecture [3–5]. By interacting with many different transcription factors, HMGA2 is an important regulator of cell growth, differentiation, apoptosis, and transformation [5]. HMGA2 protein is expressed at a high level during embryogenesis, but is hardly detectable in adult human tissues [6, 7]. HMGA2 is frequently involved in chromosomal translocations that occur in benign human tumors, such as lipomas [8], uterine leiomyomas [9], and lung hamartomas [10]. Furthermore, increased HMGA2 expression has been detected in various human epithelialtype tumors, including breast cancers [11], lung cancers [12, 13], pancreatic carcinomas [14], thyroid carcinomas [15], and gastric cancers [16]. These studies suggest that HMGA2 protein overexpression may lead to neoplastic transformation. However, there have been no reports of HMGA2 expression in hepatocellular carcinoma. In this study, we investigated HMGA2 expression in HCC to determine its clinicopathologic and prognostic value." @default.
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- W2053226757 date "2012-03-30" @default.
- W2053226757 modified "2023-09-23" @default.
- W2053226757 title "Expression of High Mobility GroupA2 is Associated with Poor Survival in Hepatocellular Carcinoma" @default.
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- W2053226757 doi "https://doi.org/10.1007/s12253-012-9514-z" @default.
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