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- W2053227199 abstract "6, 7-Dichloro-2, 3-dihydro-2-benzo[b]furancarboxylic acid derivatives having a 3, 3-N, S-disubstituted-2-propenoyl group at the 5-position were prepared by alkylation of 5-(thiocarbamoyl)acetyl derivatives of the 2, 3-dihydro-2-benzo[b]furancarboxylic acid ester or by acetal exchange reaction of 5-[3, 3-bis(alkylthio)-2-propenoyl] derivatives. Synthesis of 5-[4 and/or 5-(di)substituted-4-thiazolin-2-ylidene]acetyl-2, 3-dihydro-2-benzo[b]furancarboxylic acids was also achieved by the reaction of 2-halo-1-methoxyethyl isothiocyanate with the 5-acetyl derivative in the presence of base or through sulfide contraction of 2-[((6, 7-dichloro-2-methoxycarbonyl-2, 3-dihydrobenzo[b]furan-5-yl)carbonyl)methylthio]thiazolium bromide. Some of the compounds which were synthesized showed potent natriuretic activities in rats and mice. The structure-activity relationship is also discussed." @default.
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- W2053227199 date "1989-01-01" @default.
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- W2053227199 title "Synthetic studies on diuretics. 5-(3,3-N,S-substituted-2-propenoyl)-2,3-dihydro-2-benzo(b)furancarboxylic acids." @default.
- W2053227199 doi "https://doi.org/10.1248/cpb.37.1268" @default.
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