FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053227243> ?p ?o ?g. }

• W2053227243 endingPage "196" @default.
• W2053227243 startingPage "189" @default.
• W2053227243 abstract "Lamivudine has been shown to be an efficient drug for chronic hepatitis B (CHB) treatment.To investigate predictive factors of response, using a quantitative method with high sensitivity.We carried out a prospective trial of lamivudine in 35 patients with CHB and evidence for viral replication, regardless to their HBeAg status. Lamivudine was given for 12 months at 300 mg daily and 150 mg thereafter. Response was considered when DNA was undetectable by PCR after 6 months of treatment. Viral replication was monitored by end-point dilution PCR. Mutation associated with resistance to lamivudine was detected by DNA sequencing in non-responder patients.Response was observed in 23/35 patients (65.7%) but only in 5/15 (33.3%) HBeAg positive patients. Only three pre-treatment variables were associated to low response: HBeAg (p = 0.006), high viral load (DNA-VHB > 3 x 10(6) copies/ml) (p = 0.004) and liver HBcAg (p = 0. 0028). YMDD mutations were detected in 7/11 non-responder patients.HBeAg positive patients with high viral load show a high risk for developing drug resistance. On the other hand, HBeAg negative patients show a good response to lamivudine even with high viremia." @default.
• W2053227243 created "2016-06-24" @default.
• W2053227243 creator A5013457550 @default.
• W2053227243 creator A5020885356 @default.
• W2053227243 creator A5022386316 @default.
• W2053227243 creator A5022697744 @default.
• W2053227243 creator A5038527623 @default.
• W2053227243 creator A5067940252 @default.
• W2053227243 date "2000-08-01" @default.
• W2053227243 modified "2023-10-05" @default.
• W2053227243 title "Predictive factors for response to Lamivudine in chronic hepatitis B" @default.
• W2053227243 cites W1932939055 @default.
• W2053227243 cites W1965747579 @default.
• W2053227243 cites W1983686289 @default.
• W2053227243 cites W1994552289 @default.
• W2053227243 cites W1995079446 @default.
• W2053227243 cites W2004705863 @default.
• W2053227243 cites W2039086578 @default.
• W2053227243 cites W2042653073 @default.
• W2053227243 cites W2047480444 @default.
• W2053227243 cites W2052958019 @default.
• W2053227243 cites W2055270948 @default.
• W2053227243 cites W2058793169 @default.
• W2053227243 cites W2059956230 @default.
• W2053227243 cites W2060123467 @default.
• W2053227243 cites W2065170182 @default.
• W2053227243 cites W2077576419 @default.
• W2053227243 cites W2085990351 @default.
• W2053227243 cites W2102266647 @default.
• W2053227243 cites W2112150016 @default.
• W2053227243 cites W2124012164 @default.
• W2053227243 cites W2323719395 @default.
• W2053227243 cites W2338794667 @default.
• W2053227243 cites W2432447687 @default.
• W2053227243 doi "https://doi.org/10.1590/s0036-46652000000400003" @default.
• W2053227243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10968881" @default.
• W2053227243 hasPublicationYear "2000" @default.
• W2053227243 type Work @default.
• W2053227243 sameAs 2053227243 @default.
• W2053227243 citedByCount "23" @default.
• W2053227243 countsByYear W20532272432012 @default.
• W2053227243 countsByYear W20532272432013 @default.
• W2053227243 countsByYear W20532272432014 @default.
• W2053227243 countsByYear W20532272432015 @default.
• W2053227243 countsByYear W20532272432017 @default.
• W2053227243 countsByYear W20532272432022 @default.
• W2053227243 crossrefType "journal-article" @default.
• W2053227243 hasAuthorship W2053227243A5013457550 @default.
• W2053227243 hasAuthorship W2053227243A5020885356 @default.
• W2053227243 hasAuthorship W2053227243A5022386316 @default.
• W2053227243 hasAuthorship W2053227243A5022697744 @default.
• W2053227243 hasAuthorship W2053227243A5038527623 @default.
• W2053227243 hasAuthorship W2053227243A5067940252 @default.
• W2053227243 hasBestOaLocation W20532272431 @default.
• W2053227243 hasConcept C114851261 @default.
• W2053227243 hasConcept C126322002 @default.
• W2053227243 hasConcept C142462285 @default.
• W2053227243 hasConcept C159047783 @default.
• W2053227243 hasConcept C203014093 @default.
• W2053227243 hasConcept C2522874641 @default.
• W2053227243 hasConcept C2775940106 @default.
• W2053227243 hasConcept C2776185481 @default.
• W2053227243 hasConcept C2777382497 @default.
• W2053227243 hasConcept C2777410769 @default.
• W2053227243 hasConcept C2777869810 @default.
• W2053227243 hasConcept C2779729466 @default.
• W2053227243 hasConcept C2780593183 @default.
• W2053227243 hasConcept C3020491458 @default.
• W2053227243 hasConcept C71924100 @default.
• W2053227243 hasConcept C86803240 @default.
• W2053227243 hasConcept C89423630 @default.
• W2053227243 hasConcept C90924648 @default.
• W2053227243 hasConceptScore W2053227243C114851261 @default.
• W2053227243 hasConceptScore W2053227243C126322002 @default.
• W2053227243 hasConceptScore W2053227243C142462285 @default.
• W2053227243 hasConceptScore W2053227243C159047783 @default.
• W2053227243 hasConceptScore W2053227243C203014093 @default.
• W2053227243 hasConceptScore W2053227243C2522874641 @default.
• W2053227243 hasConceptScore W2053227243C2775940106 @default.
• W2053227243 hasConceptScore W2053227243C2776185481 @default.
• W2053227243 hasConceptScore W2053227243C2777382497 @default.
• W2053227243 hasConceptScore W2053227243C2777410769 @default.
• W2053227243 hasConceptScore W2053227243C2777869810 @default.
• W2053227243 hasConceptScore W2053227243C2779729466 @default.
• W2053227243 hasConceptScore W2053227243C2780593183 @default.
• W2053227243 hasConceptScore W2053227243C3020491458 @default.
• W2053227243 hasConceptScore W2053227243C71924100 @default.
• W2053227243 hasConceptScore W2053227243C86803240 @default.
• W2053227243 hasConceptScore W2053227243C89423630 @default.
• W2053227243 hasConceptScore W2053227243C90924648 @default.
• W2053227243 hasIssue "4" @default.
• W2053227243 hasLocation W20532272431 @default.
• W2053227243 hasLocation W20532272432 @default.
• W2053227243 hasLocation W20532272433 @default.
• W2053227243 hasOpenAccess W2053227243 @default.
• W2053227243 hasPrimaryLocation W20532272431 @default.
• W2053227243 hasRelatedWork W2053227243 @default.
• W2053227243 hasRelatedWork W2109419734 @default.

• next