FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053234296> ?p ?o ?g. }

• W2053234296 endingPage "223" @default.
• W2053234296 startingPage "215" @default.
• W2053234296 abstract "<h3>Abstract</h3> Escape variants of SARS-CoV-2 are threatening to prolong the COVID-19 pandemic. To address this challenge, we developed multivalent protein-based minibinders as potential prophylactic and therapeutic agents. Homotrimers of single minibinders and fusions of three distinct minibinders were designed to geometrically match the SARS-CoV-2 spike (S) trimer architecture and were optimized by cell-free expression and found to exhibit virtually no measurable dissociation upon binding. Cryo-electron microscopy (cryoEM) showed that these trivalent minibinders engage all three receptor binding domains on a single S trimer. The top candidates neutralize SARS-CoV-2 variants of concern with IC₅₀ values in the low pM range, resist viral escape, and provide protection in highly vulnerable human ACE2-expressing transgenic mice, both prophylactically and therapeutically. Our integrated workflow promises to accelerate the design of mutationally resilient therapeutics for pandemic preparedness. <h3>One-Sentence Summary</h3> We designed, developed, and characterized potent, trivalent miniprotein binders that provide prophylactic and therapeutic protection against emerging SARS-CoV-2 variants of concern." @default.
• W2053234296 created "2016-06-24" @default.
• W2053234296 creator A5001849463 @default.
• W2053234296 creator A5034619924 @default.
• W2053234296 date "2013-08-07" @default.
• W2053234296 modified "2023-09-28" @default.
• W2053234296 title "Skin and soft tissue infections in the military" @default.
• W2053234296 cites W1574656836 @default.
• W2053234296 cites W1611243622 @default.
• W2053234296 cites W1690516955 @default.
• W2053234296 cites W1918153539 @default.
• W2053234296 cites W1929013178 @default.
• W2053234296 cites W1978735267 @default.
• W2053234296 cites W1981522743 @default.
• W2053234296 cites W1981891935 @default.
• W2053234296 cites W1985025069 @default.
• W2053234296 cites W1991666939 @default.
• W2053234296 cites W1992763284 @default.
• W2053234296 cites W2004261125 @default.
• W2053234296 cites W2008579928 @default.
• W2053234296 cites W2014989847 @default.
• W2053234296 cites W2019110296 @default.
• W2053234296 cites W2032342216 @default.
• W2053234296 cites W2034390310 @default.
• W2053234296 cites W2039023816 @default.
• W2053234296 cites W2040098294 @default.
• W2053234296 cites W204940578 @default.
• W2053234296 cites W2050215441 @default.
• W2053234296 cites W2059143311 @default.
• W2053234296 cites W2063856968 @default.
• W2053234296 cites W2075696998 @default.
• W2053234296 cites W2081237557 @default.
• W2053234296 cites W2082173774 @default.
• W2053234296 cites W2083863237 @default.
• W2053234296 cites W2093970425 @default.
• W2053234296 cites W2095963866 @default.
• W2053234296 cites W2096882014 @default.
• W2053234296 cites W2097470551 @default.
• W2053234296 cites W2105139852 @default.
• W2053234296 cites W2112319571 @default.
• W2053234296 cites W2116080470 @default.
• W2053234296 cites W2117927613 @default.
• W2053234296 cites W2120834490 @default.
• W2053234296 cites W2121978874 @default.
• W2053234296 cites W2125675160 @default.
• W2053234296 cites W2132143957 @default.
• W2053234296 cites W2134664435 @default.
• W2053234296 cites W2149209375 @default.
• W2053234296 cites W2162851579 @default.
• W2053234296 cites W2163162582 @default.
• W2053234296 cites W2166527777 @default.
• W2053234296 cites W2168674774 @default.
• W2053234296 cites W2171875403 @default.
• W2053234296 cites W2240156003 @default.
• W2053234296 cites W2286425932 @default.
• W2053234296 cites W2310243492 @default.
• W2053234296 cites W2318027098 @default.
• W2053234296 cites W2406204477 @default.
• W2053234296 cites W2411815629 @default.
• W2053234296 cites W2419044534 @default.
• W2053234296 cites W2791065761 @default.
• W2053234296 cites W2911944729 @default.
• W2053234296 cites W3022582469 @default.
• W2053234296 cites W4245926443 @default.
• W2053234296 cites W4249288583 @default.
• W2053234296 cites W62739289 @default.
• W2053234296 cites W68596319 @default.
• W2053234296 doi "https://doi.org/10.1136/jramc-2013-000134" @default.
• W2053234296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24109144" @default.
• W2053234296 hasPublicationYear "2013" @default.
• W2053234296 type Work @default.
• W2053234296 sameAs 2053234296 @default.
• W2053234296 citedByCount "14" @default.
• W2053234296 countsByYear W20532342962013 @default.
• W2053234296 countsByYear W20532342962014 @default.
• W2053234296 countsByYear W20532342962016 @default.
• W2053234296 countsByYear W20532342962018 @default.
• W2053234296 countsByYear W20532342962019 @default.
• W2053234296 countsByYear W20532342962020 @default.
• W2053234296 countsByYear W20532342962022 @default.
• W2053234296 countsByYear W20532342962023 @default.
• W2053234296 crossrefType "journal-article" @default.
• W2053234296 hasAuthorship W2053234296A5001849463 @default.
• W2053234296 hasAuthorship W2053234296A5034619924 @default.
• W2053234296 hasConcept C12554922 @default.
• W2053234296 hasConcept C138885662 @default.
• W2053234296 hasConcept C142724271 @default.
• W2053234296 hasConcept C159047783 @default.
• W2053234296 hasConcept C171250308 @default.
• W2053234296 hasConcept C178790620 @default.
• W2053234296 hasConcept C185592680 @default.
• W2053234296 hasConcept C192562407 @default.
• W2053234296 hasConcept C194051981 @default.
• W2053234296 hasConcept C2776403692 @default.
• W2053234296 hasConcept C2778137410 @default.
• W2053234296 hasConcept C2779134260 @default.
• W2053234296 hasConcept C2779546866 @default.
• W2053234296 hasConcept C3007834351 @default.

• next