Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053235045> ?p ?o ?g. }
- W2053235045 endingPage "779" @default.
- W2053235045 startingPage "769" @default.
- W2053235045 abstract "RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium- and morpholino-functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups) of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5, was evaluated. The use of one of these polymers combining morpholine and guanidine functions at the ratio >1 and hydrophobic trimethylene carbonate groups showed a significant decrease of mRNA and protein level in HeLa cells, similar to PEI. These results highlight the potential of polycarbonate vectors for future in vivo application as an anticancer therapy." @default.
- W2053235045 created "2016-06-24" @default.
- W2053235045 creator A5005797506 @default.
- W2053235045 creator A5013803437 @default.
- W2053235045 creator A5014044373 @default.
- W2053235045 creator A5020887629 @default.
- W2053235045 creator A5021988484 @default.
- W2053235045 creator A5030053543 @default.
- W2053235045 creator A5034924627 @default.
- W2053235045 creator A5046180668 @default.
- W2053235045 creator A5084598163 @default.
- W2053235045 creator A5084708096 @default.
- W2053235045 creator A5090765919 @default.
- W2053235045 date "2015-01-30" @default.
- W2053235045 modified "2023-09-23" @default.
- W2053235045 title "Impact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability" @default.
- W2053235045 cites W1796518311 @default.
- W2053235045 cites W1965600613 @default.
- W2053235045 cites W1976811878 @default.
- W2053235045 cites W1980327660 @default.
- W2053235045 cites W1982974605 @default.
- W2053235045 cites W1985002018 @default.
- W2053235045 cites W1985106065 @default.
- W2053235045 cites W1986791363 @default.
- W2053235045 cites W1987846184 @default.
- W2053235045 cites W1989058791 @default.
- W2053235045 cites W1990887816 @default.
- W2053235045 cites W1994294376 @default.
- W2053235045 cites W1995997091 @default.
- W2053235045 cites W1998084471 @default.
- W2053235045 cites W2001609281 @default.
- W2053235045 cites W2002516695 @default.
- W2053235045 cites W2003110090 @default.
- W2053235045 cites W2004986011 @default.
- W2053235045 cites W2007347651 @default.
- W2053235045 cites W2008028087 @default.
- W2053235045 cites W2009984998 @default.
- W2053235045 cites W2010655741 @default.
- W2053235045 cites W2016954735 @default.
- W2053235045 cites W2018682207 @default.
- W2053235045 cites W2023976391 @default.
- W2053235045 cites W2030621748 @default.
- W2053235045 cites W2032250529 @default.
- W2053235045 cites W2033023421 @default.
- W2053235045 cites W2033183573 @default.
- W2053235045 cites W2033857478 @default.
- W2053235045 cites W2040101471 @default.
- W2053235045 cites W2040314827 @default.
- W2053235045 cites W2041330984 @default.
- W2053235045 cites W2041785408 @default.
- W2053235045 cites W2043821947 @default.
- W2053235045 cites W2046864596 @default.
- W2053235045 cites W2048621314 @default.
- W2053235045 cites W2054417410 @default.
- W2053235045 cites W2054688174 @default.
- W2053235045 cites W2056109863 @default.
- W2053235045 cites W2069082814 @default.
- W2053235045 cites W2077506251 @default.
- W2053235045 cites W2083263748 @default.
- W2053235045 cites W2086890417 @default.
- W2053235045 cites W2087188273 @default.
- W2053235045 cites W2092482435 @default.
- W2053235045 cites W2096619102 @default.
- W2053235045 cites W2101312385 @default.
- W2053235045 cites W2102110918 @default.
- W2053235045 cites W2107277218 @default.
- W2053235045 cites W2122140226 @default.
- W2053235045 cites W2130472233 @default.
- W2053235045 cites W2142675285 @default.
- W2053235045 cites W2153174576 @default.
- W2053235045 cites W2160969819 @default.
- W2053235045 cites W2166099168 @default.
- W2053235045 cites W2171785859 @default.
- W2053235045 cites W2475852841 @default.
- W2053235045 doi "https://doi.org/10.1021/bm501676p" @default.
- W2053235045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25603322" @default.
- W2053235045 hasPublicationYear "2015" @default.
- W2053235045 type Work @default.
- W2053235045 sameAs 2053235045 @default.
- W2053235045 citedByCount "25" @default.
- W2053235045 countsByYear W20532350452015 @default.
- W2053235045 countsByYear W20532350452016 @default.
- W2053235045 countsByYear W20532350452017 @default.
- W2053235045 countsByYear W20532350452018 @default.
- W2053235045 countsByYear W20532350452019 @default.
- W2053235045 countsByYear W20532350452020 @default.
- W2053235045 countsByYear W20532350452021 @default.
- W2053235045 countsByYear W20532350452022 @default.
- W2053235045 countsByYear W20532350452023 @default.
- W2053235045 crossrefType "journal-article" @default.
- W2053235045 hasAuthorship W2053235045A5005797506 @default.
- W2053235045 hasAuthorship W2053235045A5013803437 @default.
- W2053235045 hasAuthorship W2053235045A5014044373 @default.
- W2053235045 hasAuthorship W2053235045A5020887629 @default.
- W2053235045 hasAuthorship W2053235045A5021988484 @default.
- W2053235045 hasAuthorship W2053235045A5030053543 @default.
- W2053235045 hasAuthorship W2053235045A5034924627 @default.
- W2053235045 hasAuthorship W2053235045A5046180668 @default.