FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053236445> ?p ?o ?g. }

• W2053236445 endingPage "5290" @default.
• W2053236445 startingPage "5282" @default.
• W2053236445 abstract "Exocytosis of specialized endothelial cell secretory organelles, Weibel-Palade bodies (WPBs), is thought to play an important role in regulating hemostasis and intravascular inflammation. The major WPB core proteins are Von Willebrand factor (VWF) and its propolypeptide (Proregion), constituting more than 95% of the content. Although the composition of the WPBs can be fine-tuned to include cytokines and chemokines (eg, interleukin-8 [IL-8] and eotaxin-3), it is generally assumed that WPB exocytosis is inextricably associated with secretion of VWF. Here we show that WPBs can undergo a form of exocytosis during which VWF and Proregion are retained while smaller molecules, such as IL-8, are released. Imaging individual WPBs containing fluorescent cargo molecules revealed that during weak stimulation approximately 25% of fusion events result in a failure to release VWF or Proregion. The WPB membrane protein P-selectin was also retained; however, the membrane tetraspannin CD63 was released. Accumulation or exclusion of extracellular fluorescent dextran molecules ranging from 3 kDa to 2 mDa show that these events arise due to the formation of a fusion pore approximately 12 nm in diameter. The pore behaves as a molecular filter, allowing selective release of WPB core and membrane proteins. WPB exocytosis is not inextricably associated with secretion of VWF." @default.
• W2053236445 created "2016-06-24" @default.
• W2053236445 creator A5010188626 @default.
• W2053236445 creator A5029762926 @default.
• W2053236445 creator A5039509102 @default.
• W2053236445 creator A5051993231 @default.
• W2053236445 creator A5070255981 @default.
• W2053236445 creator A5079419435 @default.
• W2053236445 creator A5081145905 @default.
• W2053236445 date "2008-06-01" @default.
• W2053236445 modified "2023-10-16" @default.
• W2053236445 title "Selective release of molecules from Weibel-Palade bodies during a lingering kiss" @default.
• W2053236445 cites W1502078581 @default.
• W2053236445 cites W1513179886 @default.
• W2053236445 cites W1538521595 @default.
• W2053236445 cites W1969984823 @default.
• W2053236445 cites W1984384381 @default.
• W2053236445 cites W1989237374 @default.
• W2053236445 cites W1990488427 @default.
• W2053236445 cites W2000654807 @default.
• W2053236445 cites W2006986579 @default.
• W2053236445 cites W2013199099 @default.
• W2053236445 cites W2014054947 @default.
• W2053236445 cites W2014870509 @default.
• W2053236445 cites W2014918593 @default.
• W2053236445 cites W2016667273 @default.
• W2053236445 cites W2020357852 @default.
• W2053236445 cites W2022094318 @default.
• W2053236445 cites W2029309165 @default.
• W2053236445 cites W2029998262 @default.
• W2053236445 cites W2030226022 @default.
• W2053236445 cites W2032971951 @default.
• W2053236445 cites W2043169003 @default.
• W2053236445 cites W2045177940 @default.
• W2053236445 cites W2048589504 @default.
• W2053236445 cites W2049421390 @default.
• W2053236445 cites W2063186096 @default.
• W2053236445 cites W2063676540 @default.
• W2053236445 cites W2076572169 @default.
• W2053236445 cites W2085949242 @default.
• W2053236445 cites W2090552791 @default.
• W2053236445 cites W2102289204 @default.
• W2053236445 cites W2114215066 @default.
• W2053236445 cites W2115734610 @default.
• W2053236445 cites W2123878072 @default.
• W2053236445 cites W2131792212 @default.
• W2053236445 cites W2138858288 @default.
• W2053236445 cites W2161127226 @default.
• W2053236445 cites W2168150081 @default.
• W2053236445 cites W2175263209 @default.
• W2053236445 cites W4255308885 @default.
• W2053236445 doi "https://doi.org/10.1182/blood-2007-09-113746" @default.
• W2053236445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18252862" @default.
• W2053236445 hasPublicationYear "2008" @default.
• W2053236445 type Work @default.
• W2053236445 sameAs 2053236445 @default.
• W2053236445 citedByCount "81" @default.
• W2053236445 countsByYear W20532364452012 @default.
• W2053236445 countsByYear W20532364452013 @default.
• W2053236445 countsByYear W20532364452014 @default.
• W2053236445 countsByYear W20532364452015 @default.
• W2053236445 countsByYear W20532364452016 @default.
• W2053236445 countsByYear W20532364452017 @default.
• W2053236445 countsByYear W20532364452018 @default.
• W2053236445 countsByYear W20532364452019 @default.
• W2053236445 countsByYear W20532364452020 @default.
• W2053236445 countsByYear W20532364452021 @default.
• W2053236445 countsByYear W20532364452022 @default.
• W2053236445 countsByYear W20532364452023 @default.
• W2053236445 crossrefType "journal-article" @default.
• W2053236445 hasAuthorship W2053236445A5010188626 @default.
• W2053236445 hasAuthorship W2053236445A5029762926 @default.
• W2053236445 hasAuthorship W2053236445A5039509102 @default.
• W2053236445 hasAuthorship W2053236445A5051993231 @default.
• W2053236445 hasAuthorship W2053236445A5070255981 @default.
• W2053236445 hasAuthorship W2053236445A5079419435 @default.
• W2053236445 hasAuthorship W2053236445A5081145905 @default.
• W2053236445 hasBestOaLocation W20532364451 @default.
• W2053236445 hasConcept C1491633281 @default.
• W2053236445 hasConcept C175969161 @default.
• W2053236445 hasConcept C185592680 @default.
• W2053236445 hasConcept C203014093 @default.
• W2053236445 hasConcept C2779394231 @default.
• W2053236445 hasConcept C28005876 @default.
• W2053236445 hasConcept C49039625 @default.
• W2053236445 hasConcept C55493867 @default.
• W2053236445 hasConcept C79747257 @default.
• W2053236445 hasConcept C86803240 @default.
• W2053236445 hasConcept C89560881 @default.
• W2053236445 hasConcept C95444343 @default.
• W2053236445 hasConceptScore W2053236445C1491633281 @default.
• W2053236445 hasConceptScore W2053236445C175969161 @default.
• W2053236445 hasConceptScore W2053236445C185592680 @default.
• W2053236445 hasConceptScore W2053236445C203014093 @default.
• W2053236445 hasConceptScore W2053236445C2779394231 @default.
• W2053236445 hasConceptScore W2053236445C28005876 @default.
• W2053236445 hasConceptScore W2053236445C49039625 @default.
• W2053236445 hasConceptScore W2053236445C55493867 @default.

• next