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- W2053238418 abstract "DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including α-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions.To determine if DYRK1A also has a genetic association with α-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia.DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism.The rs8126696 polymorphism altered the risk of developing an α-synuclein-associated dementia.DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia." @default.
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- W2053238418 date "2012-01-01" @default.
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- W2053238418 title "A Pilot Study Examining Associations between DYRK1A and α-Synuclein Dementias" @default.
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- W2053238418 doi "https://doi.org/10.1159/000334759" @default.
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