FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053261010> ?p ?o ?g. }

• W2053261010 endingPage "e2368" @default.
• W2053261010 startingPage "e2368" @default.
• W2053261010 abstract "Antibody against CD40 is effective in enhancing immune responses to vaccines when chemically conjugated to the vaccine antigen. Unfortunately the requirement for chemical conjugation presents some difficulties in vaccine production and quality control which are compounded when multivalent vaccines are required. We explore here an alternative to chemical conjugation, involving the co-encapsulation of CD40 antibody and antigens in liposomal vehicles.Anti-mouse CD40 mAb or isotype control mAb were co-entrapped individually in cationic liposomal vehicles with pneumococcal polysaccharides or diphtheria and tetanus toxoids. Retention of CD40 binding activity upon liposomal entrapment was assessed by ELISA and flow cytometry. After subcutaneous immunization of BALB/c female mice, anti-polysaccharide and DT/TT responses were measured by ELISA. Simple co-encapsulation of CD40 antibody allowed for the retention of CD40 binding on the liposome surface, and also produced vaccines with enhanced imunogenicity. Antibody responses against both co-entrapped protein in the form of tetanus toxoid, and Streptococcus pneumoniae capsular polysaccharide, were enhanced by co-encapsulation with CD40 antibody. Surprisingly, liposomal encapsulation also appeared to decrease the toxicity of high doses of CD40 antibody as assessed by the degree of splenomegaly induced.Liposomal co-encapsulation with CD40 antibody may represent a practical means of producing more immunogenic multivalent vaccines and inducing IgG responses against polysaccharides without the need for conjugation." @default.
• W2053261010 created "2016-06-24" @default.
• W2053261010 creator A5035168354 @default.
• W2053261010 creator A5052083569 @default.
• W2053261010 creator A5057796947 @default.
• W2053261010 creator A5072477938 @default.
• W2053261010 creator A5089842300 @default.
• W2053261010 date "2008-06-04" @default.
• W2053261010 modified "2023-10-14" @default.
• W2053261010 title "Liposomal Co-Entrapment of CD40mAb Induces Enhanced IgG Responses against Bacterial Polysaccharide and Protein" @default.
• W2053261010 cites W1671359767 @default.
• W2053261010 cites W1964368704 @default.
• W2053261010 cites W1968054754 @default.
• W2053261010 cites W1994196092 @default.
• W2053261010 cites W2010480242 @default.
• W2053261010 cites W2015027328 @default.
• W2053261010 cites W2032048338 @default.
• W2053261010 cites W2053194143 @default.
• W2053261010 cites W2065557750 @default.
• W2053261010 cites W2067567916 @default.
• W2053261010 cites W2068320441 @default.
• W2053261010 cites W2069080743 @default.
• W2053261010 cites W2075357156 @default.
• W2053261010 cites W2098241001 @default.
• W2053261010 cites W2106826557 @default.
• W2053261010 cites W2116887674 @default.
• W2053261010 cites W2121602605 @default.
• W2053261010 cites W2133634704 @default.
• W2053261010 cites W2146307142 @default.
• W2053261010 cites W3025036998 @default.
• W2053261010 doi "https://doi.org/10.1371/journal.pone.0002368" @default.
• W2053261010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2387064" @default.
• W2053261010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18523585" @default.
• W2053261010 hasPublicationYear "2008" @default.
• W2053261010 type Work @default.
• W2053261010 sameAs 2053261010 @default.
• W2053261010 citedByCount "11" @default.
• W2053261010 countsByYear W20532610102013 @default.
• W2053261010 countsByYear W20532610102016 @default.
• W2053261010 countsByYear W20532610102022 @default.
• W2053261010 crossrefType "journal-article" @default.
• W2053261010 hasAuthorship W2053261010A5035168354 @default.
• W2053261010 hasAuthorship W2053261010A5052083569 @default.
• W2053261010 hasAuthorship W2053261010A5057796947 @default.
• W2053261010 hasAuthorship W2053261010A5072477938 @default.
• W2053261010 hasAuthorship W2053261010A5089842300 @default.
• W2053261010 hasBestOaLocation W20532610101 @default.
• W2053261010 hasConcept C100817775 @default.
• W2053261010 hasConcept C147483822 @default.
• W2053261010 hasConcept C159654299 @default.
• W2053261010 hasConcept C185154212 @default.
• W2053261010 hasConcept C185592680 @default.
• W2053261010 hasConcept C203014093 @default.
• W2053261010 hasConcept C2777351567 @default.
• W2053261010 hasConcept C2777367657 @default.
• W2053261010 hasConcept C2780801004 @default.
• W2053261010 hasConcept C2781253189 @default.
• W2053261010 hasConcept C33057221 @default.
• W2053261010 hasConcept C501593827 @default.
• W2053261010 hasConcept C55493867 @default.
• W2053261010 hasConcept C86803240 @default.
• W2053261010 hasConcept C8891405 @default.
• W2053261010 hasConcept C89423630 @default.
• W2053261010 hasConceptScore W2053261010C100817775 @default.
• W2053261010 hasConceptScore W2053261010C147483822 @default.
• W2053261010 hasConceptScore W2053261010C159654299 @default.
• W2053261010 hasConceptScore W2053261010C185154212 @default.
• W2053261010 hasConceptScore W2053261010C185592680 @default.
• W2053261010 hasConceptScore W2053261010C203014093 @default.
• W2053261010 hasConceptScore W2053261010C2777351567 @default.
• W2053261010 hasConceptScore W2053261010C2777367657 @default.
• W2053261010 hasConceptScore W2053261010C2780801004 @default.
• W2053261010 hasConceptScore W2053261010C2781253189 @default.
• W2053261010 hasConceptScore W2053261010C33057221 @default.
• W2053261010 hasConceptScore W2053261010C501593827 @default.
• W2053261010 hasConceptScore W2053261010C55493867 @default.
• W2053261010 hasConceptScore W2053261010C86803240 @default.
• W2053261010 hasConceptScore W2053261010C8891405 @default.
• W2053261010 hasConceptScore W2053261010C89423630 @default.
• W2053261010 hasIssue "6" @default.
• W2053261010 hasLocation W20532610101 @default.
• W2053261010 hasLocation W20532610102 @default.
• W2053261010 hasLocation W20532610103 @default.
• W2053261010 hasLocation W20532610104 @default.
• W2053261010 hasLocation W20532610105 @default.
• W2053261010 hasOpenAccess W2053261010 @default.
• W2053261010 hasPrimaryLocation W20532610101 @default.
• W2053261010 hasRelatedWork W1971781047 @default.
• W2053261010 hasRelatedWork W1978148007 @default.
• W2053261010 hasRelatedWork W2003334885 @default.
• W2053261010 hasRelatedWork W2008570575 @default.
• W2053261010 hasRelatedWork W2038923331 @default.
• W2053261010 hasRelatedWork W2050862511 @default.
• W2053261010 hasRelatedWork W2221265022 @default.
• W2053261010 hasRelatedWork W2340292413 @default.
• W2053261010 hasRelatedWork W2903752946 @default.
• W2053261010 hasRelatedWork W1926304844 @default.
• W2053261010 hasVolume "3" @default.

• next