FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053265995> ?p ?o ?g. }

• W2053265995 endingPage "1436" @default.
• W2053265995 startingPage "1427" @default.
• W2053265995 abstract "Mitochondrial respiration has been linked to insulin resistance. We studied mitochondrial respiratory capacity and substrate sensitivity in patients with type 2 diabetes (patients), and obese and lean control participants.Mitochondrial respiration was measured in permeabilised muscle fibres by respirometry. Protocols for respirometry included titration of substrates for complex I (glutamate), complex II (succinate) and both (octanoyl-carnitine). Myosin heavy chain (MHC) composition, antioxidant capacity (manganese superoxide dismutase [MnSOD]), citrate synthase activity and maximal oxygen uptake (VO2) were also determined. Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique.Insulin sensitivity was different (p < 0.05) between the groups (patients<obese controls<lean controls). MnSOD was lower in patients than in lean controls. MHC I content was lowest in patients (37 ± 11% [mean ± SE] vs 53 ± 6% and 56 ± 4%) vs obese controls and lean controls, respectively. VO2 was highest in lean controls (40 ± 3 ml min(-1) kg(-1) [mean ± SE]) compared with patients (25 ± 2) and obese controls (27 ± 2). Mitochondrial content (citrate synthase) was higher (p < 0.05) in lean controls than in patients and obese controls. When normalised for mitochondrial content by citrate synthase, mitochondrial respiratory capacity was similar in all groups. However, the half maximal substrate concentration (C(50)) for complex I was significantly lower (p = 0.03) in patients (1.1 ± 0.2 mmol/l [mean ± SE]) than in obese (2.0 ± 0.3) and lean (1.8 ± 0.3) controls. Likewise, C(50) for complex II was lower (p = 0.02) in patients (3.5 ± 0.2 mmol/l [mean ± SE]) than in obese controls (4.1 ± 0.2), but did not differ from that in lean controls (3.8 ± 0.4). Substrate sensitivity for octanoyl-carnitine did not differ between groups.Increased mitochondrial substrate sensitivity is seen in skeletal muscle from type 2 diabetic patients and is confined to non-lipid substrates. Respiratory capacity per mitochondrion is not decreased with insulin resistance." @default.
• W2053265995 created "2016-06-24" @default.
• W2053265995 creator A5016008611 @default.
• W2053265995 creator A5016534532 @default.
• W2053265995 creator A5029150072 @default.
• W2053265995 creator A5038361597 @default.
• W2053265995 creator A5045778086 @default.
• W2053265995 creator A5054145357 @default.
• W2053265995 creator A5062239390 @default.
• W2053265995 creator A5077907453 @default.
• W2053265995 creator A5091024667 @default.
• W2053265995 date "2011-03-18" @default.
• W2053265995 modified "2023-10-18" @default.
• W2053265995 title "Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes" @default.
• W2053265995 cites W1967493792 @default.
• W2053265995 cites W1976422365 @default.
• W2053265995 cites W1982699410 @default.
• W2053265995 cites W1984105528 @default.
• W2053265995 cites W1989038174 @default.
• W2053265995 cites W1990498742 @default.
• W2053265995 cites W2014671368 @default.
• W2053265995 cites W2032548272 @default.
• W2053265995 cites W2040559102 @default.
• W2053265995 cites W2043973668 @default.
• W2053265995 cites W2044523475 @default.
• W2053265995 cites W2044726034 @default.
• W2053265995 cites W2049481764 @default.
• W2053265995 cites W2054796275 @default.
• W2053265995 cites W2071572735 @default.
• W2053265995 cites W2077261489 @default.
• W2053265995 cites W2079100436 @default.
• W2053265995 cites W2095834322 @default.
• W2053265995 cites W2100580265 @default.
• W2053265995 cites W2104865391 @default.
• W2053265995 cites W2112906476 @default.
• W2053265995 cites W2123106337 @default.
• W2053265995 cites W2123250404 @default.
• W2053265995 cites W2131501155 @default.
• W2053265995 cites W2132406083 @default.
• W2053265995 cites W2146665077 @default.
• W2053265995 cites W2154768987 @default.
• W2053265995 cites W2158264554 @default.
• W2053265995 cites W2160524748 @default.
• W2053265995 cites W2165303473 @default.
• W2053265995 cites W2403578638 @default.
• W2053265995 cites W2616663063 @default.
• W2053265995 cites W4237558150 @default.
• W2053265995 cites W4253619656 @default.
• W2053265995 doi "https://doi.org/10.1007/s00125-011-2098-4" @default.
• W2053265995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21424396" @default.
• W2053265995 hasPublicationYear "2011" @default.
• W2053265995 type Work @default.
• W2053265995 sameAs 2053265995 @default.
• W2053265995 citedByCount "67" @default.
• W2053265995 countsByYear W20532659952012 @default.
• W2053265995 countsByYear W20532659952013 @default.
• W2053265995 countsByYear W20532659952014 @default.
• W2053265995 countsByYear W20532659952015 @default.
• W2053265995 countsByYear W20532659952016 @default.
• W2053265995 countsByYear W20532659952017 @default.
• W2053265995 countsByYear W20532659952018 @default.
• W2053265995 countsByYear W20532659952019 @default.
• W2053265995 countsByYear W20532659952020 @default.
• W2053265995 countsByYear W20532659952021 @default.
• W2053265995 countsByYear W20532659952022 @default.
• W2053265995 countsByYear W20532659952023 @default.
• W2053265995 crossrefType "journal-article" @default.
• W2053265995 hasAuthorship W2053265995A5016008611 @default.
• W2053265995 hasAuthorship W2053265995A5016534532 @default.
• W2053265995 hasAuthorship W2053265995A5029150072 @default.
• W2053265995 hasAuthorship W2053265995A5038361597 @default.
• W2053265995 hasAuthorship W2053265995A5045778086 @default.
• W2053265995 hasAuthorship W2053265995A5054145357 @default.
• W2053265995 hasAuthorship W2053265995A5062239390 @default.
• W2053265995 hasAuthorship W2053265995A5077907453 @default.
• W2053265995 hasAuthorship W2053265995A5091024667 @default.
• W2053265995 hasBestOaLocation W20532659951 @default.
• W2053265995 hasConcept C111133373 @default.
• W2053265995 hasConcept C126322002 @default.
• W2053265995 hasConcept C134018914 @default.
• W2053265995 hasConcept C181199279 @default.
• W2053265995 hasConcept C185592680 @default.
• W2053265995 hasConcept C2777391703 @default.
• W2053265995 hasConcept C2779306644 @default.
• W2053265995 hasConcept C28859421 @default.
• W2053265995 hasConcept C55493867 @default.
• W2053265995 hasConcept C71924100 @default.
• W2053265995 hasConcept C86803240 @default.
• W2053265995 hasConceptScore W2053265995C111133373 @default.
• W2053265995 hasConceptScore W2053265995C126322002 @default.
• W2053265995 hasConceptScore W2053265995C134018914 @default.
• W2053265995 hasConceptScore W2053265995C181199279 @default.
• W2053265995 hasConceptScore W2053265995C185592680 @default.
• W2053265995 hasConceptScore W2053265995C2777391703 @default.
• W2053265995 hasConceptScore W2053265995C2779306644 @default.
• W2053265995 hasConceptScore W2053265995C28859421 @default.
• W2053265995 hasConceptScore W2053265995C55493867 @default.
• W2053265995 hasConceptScore W2053265995C71924100 @default.

• next