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- W2053276747 abstract "Amyloid-laden tissue was obtained from five patients with either primary or secondary amyloidosis. The amyloid was isolated through a process of differential centrifugation and was examined in the electron microscope using negative-staining techniques. Two types of particles, one a 100 Å wide rod, the other a small pentagonal structure (unit structure) 90 Å in diameter, were present in all preparations. Narrow electron dense bands divided the rods at regular intervals into smaller segments so that they appeared cross-striated with a periodicity of approximately 40 Å. Frequently, however, the dense bands varied in width, suggesting that the segments were easily disunited. The unit structures seemed to be single segments lying on their flat side, thus affording an end view of the amyloid rod. They appeared to be composed of five globular sections surrounding a dense core, indicating that the amyloid rods were hollow structures possibly consisting of an array of globular units." @default.
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- W2053276747 date "1966-03-01" @default.
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- W2053276747 title "The ultrastructure of human amyloid as revealed by the negative staining technique" @default.
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- W2053276747 doi "https://doi.org/10.1016/s0022-5320(66)80075-8" @default.
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