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- W2053277169 abstract "The pharmacological effects of leaf extracts (EGb 761) from Ginkgo biloba L. are attributed to ginkgolides, bilobalide and biflavonoids. However, besides these beneficial attributes, ginkgotoxin, a B6 antivitamin which may cause epileptic convulsions, other severe neuronal disorders and even death, is also found in Ginkgo leaves and leaf-derived remedies. Because of its structural similarity to the B6 vitamers, an interaction of ginkgotoxin with enzymes involved in the vitamin B6-dependent metabolism of the human brain is possible. This led us to investigate how the neurotoxic ginkgotoxin acts in the brain. To this end the gene coding for the human pyridoxine 5′-phosphate oxidase was heterologously overexpressed in E. coli and the homogeneous enzyme was characterized. The investigation showed that the enzyme is inhibited in vitro by the synthetic vitamin B6 derivative 4′-deoxypyridoxine 5′-phosphate but not by ginkgotoxin or its 5′-phosphate." @default.
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- W2053277169 date "2009-03-13" @default.
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- W2053277169 title "Influence of Antivitamins Ginkgotoxin 5′-Phosphate and Deoxypyridoxine 5′-Phosphate on Human Pyridoxine 5′-Phosphate Oxidase" @default.
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- W2053277169 doi "https://doi.org/10.1055/s-0029-1185482" @default.
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