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- W2053281013 abstract "This study, conducted under the auspices of ANDEM, was aimed at determining the reasons for the inefficacy of platelet transfusions for thrombocytopenia of central origin, and to establish recommendations for therapy and prevention. It was based on a critical review of the literature. Three main causes of inefficacy were identified: an immunological conflict (mainly anti-HLA alloimmunization), clinical status, and the quality of platelet preparations (especially storage time). Our recommendations depend on several factors, such as the degree of urgency, the cause of platelet refractoriness, clinical status and the availability of platelet preparations. The mainstay of the recommendations is prevention, based on the quality of platelet preparations (as fresh as possible, in adequate number preferably obtained by apheresis and ABO compatible) and on the prevention of anti-HLA alloimmunization." @default.
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- W2053281013 creator A5021249110 @default.
- W2053281013 date "1995-01-01" @default.
- W2053281013 modified "2023-09-30" @default.
- W2053281013 title "Inefficacité des transfusions de plaquettes au cours des thrombopénies d'origine centrale" @default.
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- W2053281013 doi "https://doi.org/10.1016/s1246-7820(05)80020-5" @default.
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