FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053282617> ?p ?o ?g. }

• W2053282617 endingPage "1753" @default.
• W2053282617 startingPage "1745" @default.
• W2053282617 abstract "Abstract Objective Recently, Swedish members of the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) provided evidence that smoking may trigger RA‐specific immune reactions to citrullinated protein in carriers of HLA–DR shared epitope alleles. In an effort to confirm this interaction between smoking and shared epitope alleles, we performed a case‐only analysis of 3 North American RA cohorts. Methods A total of 2,476 white patients with RA were studied, 1,105 from the North American Rheumatoid Arthritis Consortium (NARAC) family collection, 753 from the National Inception Cohort of Rheumatoid Arthritis Patients (Inception Cohort), and 618 from the Study of New Onset Rheumatoid Arthritis (SONORA). All patients were HLA–DRB1 typed, and tested for anti–cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor. Information about smoking history was obtained by questionnaire. Results A significant association was found between smoking and the presence of anti‐CCP in the NARAC and the Inception Cohort, but not in the SONORA. The shared epitope alleles consistently correlated with anti‐CCP in all 3 populations. Using multiple logistic regression analyses, shared epitope alleles were still the most significant risk factor for anti‐CCP positivity. Weak evidence of gene–environment interaction between smoking and shared epitope alleles for anti‐CCP formation was found only in the NARAC. Conclusion Unlike the EIRA data, we could not confirm a major gene–environment interaction for anti‐CCP formation between shared epitope alleles and smoking in 3 North American RA cohorts. Our data indicate a need for further studies to address the full range of environmental factors other than smoking that may be associated with citrullination and RA." @default.
• W2053282617 created "2016-06-24" @default.
• W2053282617 creator A5007547414 @default.
• W2053282617 creator A5011580404 @default.
• W2053282617 creator A5030335777 @default.
• W2053282617 creator A5031499331 @default.
• W2053282617 creator A5041371546 @default.
• W2053282617 creator A5044134293 @default.
• W2053282617 creator A5051069161 @default.
• W2053282617 creator A5058419289 @default.
• W2053282617 creator A5066232855 @default.
• W2053282617 creator A5068692530 @default.
• W2053282617 creator A5069410791 @default.
• W2053282617 creator A5079680522 @default.
• W2053282617 creator A5082248535 @default.
• W2053282617 creator A5082388906 @default.
• W2053282617 creator A5082819294 @default.
• W2053282617 date "2007-05-25" @default.
• W2053282617 modified "2023-10-17" @default.
• W2053282617 title "Interaction between smoking, the shared epitope, and anti–cyclic citrullinated peptide: A mixed picture in three large North American rheumatoid arthritis cohorts" @default.
• W2053282617 cites W1493966058 @default.
• W2053282617 cites W1646831595 @default.
• W2053282617 cites W1831078481 @default.
• W2053282617 cites W1963603430 @default.
• W2053282617 cites W1964890547 @default.
• W2053282617 cites W1974774736 @default.
• W2053282617 cites W1977327861 @default.
• W2053282617 cites W1980263659 @default.
• W2053282617 cites W1987055888 @default.
• W2053282617 cites W1993027018 @default.
• W2053282617 cites W2006835355 @default.
• W2053282617 cites W2008649874 @default.
• W2053282617 cites W2011188299 @default.
• W2053282617 cites W2015865604 @default.
• W2053282617 cites W2020695349 @default.
• W2053282617 cites W2025408360 @default.
• W2053282617 cites W2029764393 @default.
• W2053282617 cites W2034839671 @default.
• W2053282617 cites W2037431375 @default.
• W2053282617 cites W2039684625 @default.
• W2053282617 cites W2049872934 @default.
• W2053282617 cites W2062606344 @default.
• W2053282617 cites W2063213943 @default.
• W2053282617 cites W2066393616 @default.
• W2053282617 cites W2066629760 @default.
• W2053282617 cites W2078327260 @default.
• W2053282617 cites W2082688799 @default.
• W2053282617 cites W2095138905 @default.
• W2053282617 cites W2102079012 @default.
• W2053282617 cites W2103089222 @default.
• W2053282617 cites W2107005433 @default.
• W2053282617 cites W2114378805 @default.
• W2053282617 cites W2118133160 @default.
• W2053282617 cites W2122176733 @default.
• W2053282617 cites W2147914485 @default.
• W2053282617 cites W2150004178 @default.
• W2053282617 cites W2152348310 @default.
• W2053282617 cites W2154227361 @default.
• W2053282617 cites W2160517055 @default.
• W2053282617 cites W2163652380 @default.
• W2053282617 cites W2171505477 @default.
• W2053282617 cites W2172150816 @default.
• W2053282617 cites W4249951249 @default.
• W2053282617 doi "https://doi.org/10.1002/art.22703" @default.
• W2053282617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17530703" @default.
• W2053282617 hasPublicationYear "2007" @default.
• W2053282617 type Work @default.
• W2053282617 sameAs 2053282617 @default.
• W2053282617 citedByCount "149" @default.
• W2053282617 countsByYear W20532826172012 @default.
• W2053282617 countsByYear W20532826172013 @default.
• W2053282617 countsByYear W20532826172014 @default.
• W2053282617 countsByYear W20532826172015 @default.
• W2053282617 countsByYear W20532826172016 @default.
• W2053282617 countsByYear W20532826172017 @default.
• W2053282617 countsByYear W20532826172018 @default.
• W2053282617 countsByYear W20532826172019 @default.
• W2053282617 countsByYear W20532826172020 @default.
• W2053282617 countsByYear W20532826172021 @default.
• W2053282617 countsByYear W20532826172022 @default.
• W2053282617 crossrefType "journal-article" @default.
• W2053282617 hasAuthorship W2053282617A5007547414 @default.
• W2053282617 hasAuthorship W2053282617A5011580404 @default.
• W2053282617 hasAuthorship W2053282617A5030335777 @default.
• W2053282617 hasAuthorship W2053282617A5031499331 @default.
• W2053282617 hasAuthorship W2053282617A5041371546 @default.
• W2053282617 hasAuthorship W2053282617A5044134293 @default.
• W2053282617 hasAuthorship W2053282617A5051069161 @default.
• W2053282617 hasAuthorship W2053282617A5058419289 @default.
• W2053282617 hasAuthorship W2053282617A5066232855 @default.
• W2053282617 hasAuthorship W2053282617A5068692530 @default.
• W2053282617 hasAuthorship W2053282617A5069410791 @default.
• W2053282617 hasAuthorship W2053282617A5079680522 @default.
• W2053282617 hasAuthorship W2053282617A5082248535 @default.
• W2053282617 hasAuthorship W2053282617A5082388906 @default.
• W2053282617 hasAuthorship W2053282617A5082819294 @default.
• W2053282617 hasConcept C104317684 @default.
• W2053282617 hasConcept C126322002 @default.

• next