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- W2053283995 abstract "Background Little is known about factors that predict first lifetime episodes of major depression in middle-aged women. It is not known whether health-related factors and life stress pose more or less of a risk to the onset of clinical depression than does the menopausal transition. Method The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was used to assess diagnoses of lifetime, annual and current major depression in a community-based sample of premenopausal or early perimenopausal African American and White women. Menstrual cycle characteristics, psychosocial and health-related factors, and blood samples for assay of reproductive hormones were obtained annually. Two hundred and sixty-six women without a history of major depression at baseline constituted the cohort for the current analyses. Results Over 7 years of follow-up, 42 (15.8%) women met criteria for a diagnosis of major depression. Frequent vasomotor symptoms (VMS; hot flashes and/or night sweats) (HR 2.14, p =0.03) were a significant predictor of major depression in univariate analyses. After simultaneous adjustment for multiple predictors in Cox proportional hazards analyses, frequent VMS were no longer significant; lifetime history of an anxiety disorder (HR 2.20, p =0.02) and role limitations due to physical health (HR 1.88, p =0.07) at baseline and a very stressful life event (HR 2.25, p =0.04) prior to depression onset predicted a first episode of major depression. Conclusions Both earlier (e.g. history of anxiety disorders) and more proximal factors (e.g. life stress) may be more important than VMS in contributing to a first episode of major depression during midlife." @default.
- W2053283995 created "2016-06-24" @default.
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- W2053283995 date "2008-04-01" @default.
- W2053283995 modified "2023-09-28" @default.
- W2053283995 title "Predictors of first lifetime episodes of major depression in midlife women" @default.
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- W2053283995 doi "https://doi.org/10.1017/s0033291708003218" @default.
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