Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053287858> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2053287858 endingPage "135" @default.
- W2053287858 startingPage "129" @default.
- W2053287858 abstract "The Schild analysis is certainly the most reliable method for antagonism studies. The Schild regression allows one to determine the parameter of the Schild-slope, which represents a powerful diagnostic tool when investigating the nature of an antagonist and, consequently, to evaluate its potency. Nevertheless, in functional pharmacology, often practical reasons lead the experimenter to obtain an inhibition curve for the antagonist and calculate its potency by means of equations, which can be considered as a derivation of the Cheng-Prusoff analysis. This approach is considered theoretically invalid, because it does not allow to know the exact nature of the antagonism, and thus the evaluation of the antagonist dissociation constant can be meaningless. In this paper, a new method is proposed, which, by means of an equation closely similar to the Schild one, permits one to obtain a linear regression analysis, giving a slope value absolutely equivalent to the Schild-slope. This method allows us to determine both the nature and the potency of an antagonist, and requires an experimental procedure substantially analogous to the one performed to obtain an inhibition curve." @default.
- W2053287858 created "2016-06-24" @default.
- W2053287858 creator A5008782167 @default.
- W2053287858 date "1998-04-01" @default.
- W2053287858 modified "2023-09-23" @default.
- W2053287858 title "An alternative method to evaluate the nature of an antagonist and its potency: a theoretical approach" @default.
- W2053287858 cites W1836006076 @default.
- W2053287858 cites W1853270178 @default.
- W2053287858 cites W1984260910 @default.
- W2053287858 cites W1999017878 @default.
- W2053287858 cites W2012054450 @default.
- W2053287858 cites W2021169218 @default.
- W2053287858 cites W2028052643 @default.
- W2053287858 cites W2039628177 @default.
- W2053287858 cites W2050795206 @default.
- W2053287858 cites W2057971042 @default.
- W2053287858 cites W2059501084 @default.
- W2053287858 cites W2061657842 @default.
- W2053287858 cites W2064088278 @default.
- W2053287858 cites W2068579383 @default.
- W2053287858 cites W2074631079 @default.
- W2053287858 cites W2130560587 @default.
- W2053287858 cites W2167381827 @default.
- W2053287858 cites W2228849827 @default.
- W2053287858 cites W651444216 @default.
- W2053287858 cites W1919525914 @default.
- W2053287858 doi "https://doi.org/10.1016/s1056-8719(98)00013-6" @default.
- W2053287858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9741386" @default.
- W2053287858 hasPublicationYear "1998" @default.
- W2053287858 type Work @default.
- W2053287858 sameAs 2053287858 @default.
- W2053287858 citedByCount "4" @default.
- W2053287858 crossrefType "journal-article" @default.
- W2053287858 hasAuthorship W2053287858A5008782167 @default.
- W2053287858 hasConcept C105795698 @default.
- W2053287858 hasConcept C126322002 @default.
- W2053287858 hasConcept C152877465 @default.
- W2053287858 hasConcept C170493617 @default.
- W2053287858 hasConcept C185592680 @default.
- W2053287858 hasConcept C199343813 @default.
- W2053287858 hasConcept C202751555 @default.
- W2053287858 hasConcept C2776885963 @default.
- W2053287858 hasConcept C2777383412 @default.
- W2053287858 hasConcept C2777686260 @default.
- W2053287858 hasConcept C28826006 @default.
- W2053287858 hasConcept C33923547 @default.
- W2053287858 hasConcept C48921125 @default.
- W2053287858 hasConcept C55493867 @default.
- W2053287858 hasConcept C57992300 @default.
- W2053287858 hasConcept C71924100 @default.
- W2053287858 hasConcept C75214554 @default.
- W2053287858 hasConceptScore W2053287858C105795698 @default.
- W2053287858 hasConceptScore W2053287858C126322002 @default.
- W2053287858 hasConceptScore W2053287858C152877465 @default.
- W2053287858 hasConceptScore W2053287858C170493617 @default.
- W2053287858 hasConceptScore W2053287858C185592680 @default.
- W2053287858 hasConceptScore W2053287858C199343813 @default.
- W2053287858 hasConceptScore W2053287858C202751555 @default.
- W2053287858 hasConceptScore W2053287858C2776885963 @default.
- W2053287858 hasConceptScore W2053287858C2777383412 @default.
- W2053287858 hasConceptScore W2053287858C2777686260 @default.
- W2053287858 hasConceptScore W2053287858C28826006 @default.
- W2053287858 hasConceptScore W2053287858C33923547 @default.
- W2053287858 hasConceptScore W2053287858C48921125 @default.
- W2053287858 hasConceptScore W2053287858C55493867 @default.
- W2053287858 hasConceptScore W2053287858C57992300 @default.
- W2053287858 hasConceptScore W2053287858C71924100 @default.
- W2053287858 hasConceptScore W2053287858C75214554 @default.
- W2053287858 hasIssue "3" @default.
- W2053287858 hasLocation W20532878581 @default.
- W2053287858 hasLocation W20532878582 @default.
- W2053287858 hasOpenAccess W2053287858 @default.
- W2053287858 hasPrimaryLocation W20532878581 @default.
- W2053287858 hasRelatedWork W1971190350 @default.
- W2053287858 hasRelatedWork W203123583 @default.
- W2053287858 hasRelatedWork W2041676579 @default.
- W2053287858 hasRelatedWork W2053287858 @default.
- W2053287858 hasRelatedWork W2072862004 @default.
- W2053287858 hasRelatedWork W2138542862 @default.
- W2053287858 hasRelatedWork W2159599069 @default.
- W2053287858 hasRelatedWork W2245580247 @default.
- W2053287858 hasRelatedWork W2950251366 @default.
- W2053287858 hasRelatedWork W3152386190 @default.
- W2053287858 hasVolume "39" @default.
- W2053287858 isParatext "false" @default.
- W2053287858 isRetracted "false" @default.
- W2053287858 magId "2053287858" @default.
- W2053287858 workType "article" @default.