FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053289695> ?p ?o ?g. }

• W2053289695 endingPage "C1285" @default.
• W2053289695 startingPage "C1278" @default.
• W2053289695 abstract "Adult skeletal muscle possesses remarkable potential for growth in response to mechanical loading; however, many of the cellular and molecular mechanisms involved remain undefined. The hypothesis of this study was that the extracellular serine protease, urokinase-type plasminogen activator (uPA), is required for muscle hypertrophy, in part by promoting macrophage accumulation in muscle subjected to increased mechanical loading. Compensatory muscle hypertrophy was induced in mouse plantaris (PLT) muscles by surgical ablation of synergist muscles. Following synergist ablation, PLT muscles in wild-type mice demonstrated edema and infiltration of neutrophils and macrophages but an absence of overt muscle fiber damage. Sham procedures resulted in no edema or accumulation of inflammatory cells. In addition, synergist ablation was associated with a large increase in activity of uPA in the PLT muscle. uPA-null mice demonstrated complete abrogation of compensatory hypertrophy associated with reduced macrophage accumulation, indicating that uPA is required for hypertrophy. Macrophages isolated from wild-type PLT muscle during compensatory hypertrophy expressed uPA and IGF-I, both of which may contribute to hypertrophy. To determine whether macrophages are required for muscle hypertrophy, clodronate liposomes were administered to deplete macrophages in wild-type mice; this resulted in reduced muscle hypertrophy. Decreased macrophage accumulation was associated with reduced cell proliferation but did not alter signaling through the mammalian target of rapamycin pathway. These data indicate that uPA and macrophages are required for muscle hypertrophy following synergist ablation." @default.
• W2053289695 created "2016-06-24" @default.
• W2053289695 creator A5005993605 @default.
• W2053289695 creator A5015045396 @default.
• W2053289695 creator A5021808442 @default.
• W2053289695 creator A5044049048 @default.
• W2053289695 creator A5051527512 @default.
• W2053289695 creator A5073977674 @default.
• W2053289695 creator A5079003683 @default.
• W2053289695 date "2007-10-01" @default.
• W2053289695 modified "2023-10-16" @default.
• W2053289695 title "Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice" @default.
• W2053289695 cites W1482629448 @default.
• W2053289695 cites W1528461628 @default.
• W2053289695 cites W1578893636 @default.
• W2053289695 cites W1883556796 @default.
• W2053289695 cites W1926614894 @default.
• W2053289695 cites W1964941751 @default.
• W2053289695 cites W1965044262 @default.
• W2053289695 cites W1977380331 @default.
• W2053289695 cites W1977451666 @default.
• W2053289695 cites W1977481096 @default.
• W2053289695 cites W1986238056 @default.
• W2053289695 cites W1989793664 @default.
• W2053289695 cites W1991608171 @default.
• W2053289695 cites W1993677761 @default.
• W2053289695 cites W2001038886 @default.
• W2053289695 cites W2007293837 @default.
• W2053289695 cites W2007561892 @default.
• W2053289695 cites W2017200318 @default.
• W2053289695 cites W2017347652 @default.
• W2053289695 cites W2027093378 @default.
• W2053289695 cites W2036349977 @default.
• W2053289695 cites W2038689279 @default.
• W2053289695 cites W2042998208 @default.
• W2053289695 cites W2054314636 @default.
• W2053289695 cites W2062760760 @default.
• W2053289695 cites W2081305406 @default.
• W2053289695 cites W2084652366 @default.
• W2053289695 cites W2092565468 @default.
• W2053289695 cites W2098940221 @default.
• W2053289695 cites W2107290701 @default.
• W2053289695 cites W2109272075 @default.
• W2053289695 cites W2110228756 @default.
• W2053289695 cites W2112820818 @default.
• W2053289695 cites W2115825738 @default.
• W2053289695 cites W2116738170 @default.
• W2053289695 cites W2132886183 @default.
• W2053289695 cites W2133183478 @default.
• W2053289695 cites W2133207114 @default.
• W2053289695 cites W2141359943 @default.
• W2053289695 cites W2147680529 @default.
• W2053289695 cites W2157439116 @default.
• W2053289695 cites W2180586567 @default.
• W2053289695 cites W2186070551 @default.
• W2053289695 cites W2266044096 @default.
• W2053289695 cites W2341794603 @default.
• W2053289695 cites W2474552216 @default.
• W2053289695 doi "https://doi.org/10.1152/ajpcell.00201.2007" @default.
• W2053289695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17652428" @default.
• W2053289695 hasPublicationYear "2007" @default.
• W2053289695 type Work @default.
• W2053289695 sameAs 2053289695 @default.
• W2053289695 citedByCount "68" @default.
• W2053289695 countsByYear W20532896952012 @default.
• W2053289695 countsByYear W20532896952013 @default.
• W2053289695 countsByYear W20532896952014 @default.
• W2053289695 countsByYear W20532896952015 @default.
• W2053289695 countsByYear W20532896952016 @default.
• W2053289695 countsByYear W20532896952017 @default.
• W2053289695 countsByYear W20532896952018 @default.
• W2053289695 countsByYear W20532896952019 @default.
• W2053289695 countsByYear W20532896952020 @default.
• W2053289695 countsByYear W20532896952021 @default.
• W2053289695 countsByYear W20532896952022 @default.
• W2053289695 countsByYear W20532896952023 @default.
• W2053289695 crossrefType "journal-article" @default.
• W2053289695 hasAuthorship W2053289695A5005993605 @default.
• W2053289695 hasAuthorship W2053289695A5015045396 @default.
• W2053289695 hasAuthorship W2053289695A5021808442 @default.
• W2053289695 hasAuthorship W2053289695A5044049048 @default.
• W2053289695 hasAuthorship W2053289695A5051527512 @default.
• W2053289695 hasAuthorship W2053289695A5073977674 @default.
• W2053289695 hasAuthorship W2053289695A5079003683 @default.
• W2053289695 hasConcept C126322002 @default.
• W2053289695 hasConcept C134018914 @default.
• W2053289695 hasConcept C167414201 @default.
• W2053289695 hasConcept C185592680 @default.
• W2053289695 hasConcept C202751555 @default.
• W2053289695 hasConcept C207200792 @default.
• W2053289695 hasConcept C2779244956 @default.
• W2053289695 hasConcept C2779679481 @default.
• W2053289695 hasConcept C2779959927 @default.
• W2053289695 hasConcept C55493867 @default.
• W2053289695 hasConcept C71924100 @default.
• W2053289695 hasConcept C86803240 @default.
• W2053289695 hasConceptScore W2053289695C126322002 @default.
• W2053289695 hasConceptScore W2053289695C134018914 @default.

• next