FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053294433> ?p ?o ?g. }

• W2053294433 endingPage "1043" @default.
• W2053294433 startingPage "1035" @default.
• W2053294433 abstract "To test different approaches of evaluation of the ErbB2 status in a large series of human transitional cell carcinoma (TCC) of the bladder with the prospect of finding targeted therapies.ErbB2 status of 73 human TCC samples was analyzed by both immunohistochemistry (IHC) and by quantification of mRNA levels of expression using real-time reverse transcription-polymerase chain reaction (RT-PCR). Additionally, 18 bladder samples were studied for ERBB2 gene amplification by real-time quantitative PCR.Twenty-five tumors (34.2%) overexpressed ERBB2 mRNA compared to normal bladder samples; this alteration appeared in low-grade and low-stage tumors (pTaG1). Twenty-four (32.9%) tumors showed moderate (++) or strong (+++) immunostaining. A very strong agreement was found between the two methods (kappa = 0.97, 95% confidence interval, 0.90-1). ErbB2 status was not associated with tumor stage. Of the 18 bladder samples tested for ERBB2 gene amplification, only one showed ERBB2 DNA amplification.ErbB2 overexpression occurs in about one third of bladder TCCs. This overexpression can be detected by RT-PCR with a very good correlation with IHC. RT-PCR can therefore be used for cases considered doubtful on IHC rather than gene amplification studies because, in TCC, gene amplification is not the predominant mechanism of both mRNA and protein overexpression. Accurate quantification of ErbB2 status is mandatory for the use of anti-ErbB2-targeted therapies in bladder TCC." @default.
• W2053294433 created "2016-06-24" @default.
• W2053294433 creator A5016517378 @default.
• W2053294433 creator A5016806582 @default.
• W2053294433 creator A5022121572 @default.
• W2053294433 creator A5036543006 @default.
• W2053294433 creator A5037964830 @default.
• W2053294433 creator A5043924500 @default.
• W2053294433 creator A5072922609 @default.
• W2053294433 creator A5083305562 @default.
• W2053294433 creator A5086511542 @default.
• W2053294433 date "2006-06-01" @default.
• W2053294433 modified "2023-10-14" @default.
• W2053294433 title "Is Quantitative Real-Time RT-PCR an Adjunct to Immunohistochemistry for the Evaluation of ErbB2 Status in Transitional Carcinoma of the Bladder?" @default.
• W2053294433 cites W1485446176 @default.
• W2053294433 cites W1566258185 @default.
• W2053294433 cites W1672915283 @default.
• W2053294433 cites W1971605007 @default.
• W2053294433 cites W1984692133 @default.
• W2053294433 cites W1985699055 @default.
• W2053294433 cites W1989078916 @default.
• W2053294433 cites W2020257606 @default.
• W2053294433 cites W2036723378 @default.
• W2053294433 cites W2037521712 @default.
• W2053294433 cites W2047587366 @default.
• W2053294433 cites W2053673624 @default.
• W2053294433 cites W2060447952 @default.
• W2053294433 cites W2063207291 @default.
• W2053294433 cites W2065897266 @default.
• W2053294433 cites W2072894518 @default.
• W2053294433 cites W2079620341 @default.
• W2053294433 cites W2090705049 @default.
• W2053294433 cites W2102917490 @default.
• W2053294433 cites W2106636644 @default.
• W2053294433 cites W2119352376 @default.
• W2053294433 cites W2125273101 @default.
• W2053294433 cites W2133407636 @default.
• W2053294433 cites W2133439946 @default.
• W2053294433 cites W2139567146 @default.
• W2053294433 cites W2140912807 @default.
• W2053294433 cites W2141393790 @default.
• W2053294433 cites W2143800923 @default.
• W2053294433 cites W2151729715 @default.
• W2053294433 cites W2156966632 @default.
• W2053294433 cites W2159602607 @default.
• W2053294433 cites W2164777277 @default.
• W2053294433 cites W2165534156 @default.
• W2053294433 cites W2166791970 @default.
• W2053294433 cites W2167427006 @default.
• W2053294433 cites W2182514684 @default.
• W2053294433 cites W21899765 @default.
• W2053294433 cites W2396583395 @default.
• W2053294433 cites W2411605089 @default.
• W2053294433 cites W2471684097 @default.
• W2053294433 cites W2994198383 @default.
• W2053294433 doi "https://doi.org/10.1016/j.eururo.2006.01.021" @default.
• W2053294433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16466848" @default.
• W2053294433 hasPublicationYear "2006" @default.
• W2053294433 type Work @default.
• W2053294433 sameAs 2053294433 @default.
• W2053294433 citedByCount "5" @default.
• W2053294433 countsByYear W20532944332013 @default.
• W2053294433 countsByYear W20532944332016 @default.
• W2053294433 countsByYear W20532944332021 @default.
• W2053294433 countsByYear W20532944332022 @default.
• W2053294433 crossrefType "journal-article" @default.
• W2053294433 hasAuthorship W2053294433A5016517378 @default.
• W2053294433 hasAuthorship W2053294433A5016806582 @default.
• W2053294433 hasAuthorship W2053294433A5022121572 @default.
• W2053294433 hasAuthorship W2053294433A5036543006 @default.
• W2053294433 hasAuthorship W2053294433A5037964830 @default.
• W2053294433 hasAuthorship W2053294433A5043924500 @default.
• W2053294433 hasAuthorship W2053294433A5072922609 @default.
• W2053294433 hasAuthorship W2053294433A5083305562 @default.
• W2053294433 hasAuthorship W2053294433A5086511542 @default.
• W2053294433 hasConcept C104317684 @default.
• W2053294433 hasConcept C121608353 @default.
• W2053294433 hasConcept C126322002 @default.
• W2053294433 hasConcept C142724271 @default.
• W2053294433 hasConcept C146357865 @default.
• W2053294433 hasConcept C150194340 @default.
• W2053294433 hasConcept C151730666 @default.
• W2053294433 hasConcept C204232928 @default.
• W2053294433 hasConcept C2777546739 @default.
• W2053294433 hasConcept C2778065480 @default.
• W2053294433 hasConcept C2779762690 @default.
• W2053294433 hasConcept C2780352672 @default.
• W2053294433 hasConcept C4224716 @default.
• W2053294433 hasConcept C4692481 @default.
• W2053294433 hasConcept C48023723 @default.
• W2053294433 hasConcept C49105822 @default.
• W2053294433 hasConcept C55493867 @default.
• W2053294433 hasConcept C71924100 @default.
• W2053294433 hasConcept C7602840 @default.
• W2053294433 hasConcept C86803240 @default.
• W2053294433 hasConceptScore W2053294433C104317684 @default.
• W2053294433 hasConceptScore W2053294433C121608353 @default.
• W2053294433 hasConceptScore W2053294433C126322002 @default.

• next