FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053294559> ?p ?o ?g. }

• W2053294559 endingPage "270" @default.
• W2053294559 startingPage "263" @default.
• W2053294559 abstract "Purpose of review Antineutrophil cytoplasmic autoantibodies (ANCAs) are associated with vasculitis. Current therapy involves administration of toxic therapy that is not optimally effective. This review will summarize evidence for the pathogenicity of ANCAs, which will suggest possible strategies for improving treatment. Recent findings Pauci-immune small vessel vasculitis is associated with antibodies against myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). One research group has reported a high frequency of autoantibodies against lysosomal-associated membrane protein 2 (LAMP-2) in patients with MPO-ANCA or PR3-ANCA. Epigenetic dysregulation appears to be the basis for increased MPO and PR3 neutrophil gene expression in ANCA disease. Release of neutrophil extracellular traps may be involved in initiating the ANCA autoimmune response and causing vessel injury. Generation of C5a by alternative pathway activation is involved in pathogenesis in mouse models. Intervention strategies in mice that target antigens, antibodies and inflammatory signaling pathways may translate into novel therapies. Animal models of LAMP-ANCA and PR3-ANCA disease have been proposed. Molecular mimicry and responses to complementary peptides may be initiating events for ANCAs. T cells, including regulatory T cells, have been implicated in the origin and modulation of the ANCAs, as well as in the induction of tissue injury. Summary Our basic understanding of the origins and pathogenesis of ANCA disease is advancing. This deeper understanding already has spawned novel therapies that are being investigated in clinical trials. This brief review shows that there are more questions than answers, and new questions are emerging faster than existing questions are being answered." @default.
• W2053294559 created "2016-06-24" @default.
• W2053294559 creator A5032512383 @default.
• W2053294559 creator A5066638505 @default.
• W2053294559 creator A5086851939 @default.
• W2053294559 date "2011-05-01" @default.
• W2053294559 modified "2023-09-25" @default.
• W2053294559 title "Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis" @default.
• W2053294559 cites W1482409286 @default.
• W2053294559 cites W1585554327 @default.
• W2053294559 cites W1596601321 @default.
• W2053294559 cites W161951250 @default.
• W2053294559 cites W1794404623 @default.
• W2053294559 cites W1968598953 @default.
• W2053294559 cites W1977255574 @default.
• W2053294559 cites W1978173837 @default.
• W2053294559 cites W1981778251 @default.
• W2053294559 cites W1981991010 @default.
• W2053294559 cites W1993041716 @default.
• W2053294559 cites W1999511105 @default.
• W2053294559 cites W2005290499 @default.
• W2053294559 cites W2007669811 @default.
• W2053294559 cites W2007755878 @default.
• W2053294559 cites W2008007268 @default.
• W2053294559 cites W2019274057 @default.
• W2053294559 cites W2023134552 @default.
• W2053294559 cites W2038085074 @default.
• W2053294559 cites W2043756611 @default.
• W2053294559 cites W2058445558 @default.
• W2053294559 cites W2081816705 @default.
• W2053294559 cites W2085202825 @default.
• W2053294559 cites W2086183699 @default.
• W2053294559 cites W2090906385 @default.
• W2053294559 cites W2097612833 @default.
• W2053294559 cites W2100468967 @default.
• W2053294559 cites W2100505646 @default.
• W2053294559 cites W2103364032 @default.
• W2053294559 cites W2104599968 @default.
• W2053294559 cites W2106211656 @default.
• W2053294559 cites W2107254198 @default.
• W2053294559 cites W2117393504 @default.
• W2053294559 cites W2118702066 @default.
• W2053294559 cites W2122595921 @default.
• W2053294559 cites W2123444939 @default.
• W2053294559 cites W2123714651 @default.
• W2053294559 cites W2130513186 @default.
• W2053294559 cites W2130910156 @default.
• W2053294559 cites W2131195925 @default.
• W2053294559 cites W2134545344 @default.
• W2053294559 cites W2136087277 @default.
• W2053294559 cites W2139723647 @default.
• W2053294559 cites W2139903965 @default.
• W2053294559 cites W2140431074 @default.
• W2053294559 cites W2141074379 @default.
• W2053294559 cites W2142785209 @default.
• W2053294559 cites W2146854727 @default.
• W2053294559 cites W2151033853 @default.
• W2053294559 cites W2154252857 @default.
• W2053294559 cites W2156627099 @default.
• W2053294559 cites W2164726299 @default.
• W2053294559 cites W2165269524 @default.
• W2053294559 cites W2166599546 @default.
• W2053294559 cites W2167369293 @default.
• W2053294559 cites W2167430418 @default.
• W2053294559 cites W2182473668 @default.
• W2053294559 cites W4233885503 @default.
• W2053294559 doi "https://doi.org/10.1097/mnh.0b013e3283456731" @default.
• W2053294559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096782" @default.
• W2053294559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21422922" @default.
• W2053294559 hasPublicationYear "2011" @default.
• W2053294559 type Work @default.
• W2053294559 sameAs 2053294559 @default.
• W2053294559 citedByCount "105" @default.
• W2053294559 countsByYear W20532945592012 @default.
• W2053294559 countsByYear W20532945592013 @default.
• W2053294559 countsByYear W20532945592014 @default.
• W2053294559 countsByYear W20532945592015 @default.
• W2053294559 countsByYear W20532945592016 @default.
• W2053294559 countsByYear W20532945592017 @default.
• W2053294559 countsByYear W20532945592018 @default.
• W2053294559 countsByYear W20532945592019 @default.
• W2053294559 countsByYear W20532945592020 @default.
• W2053294559 countsByYear W20532945592021 @default.
• W2053294559 countsByYear W20532945592022 @default.
• W2053294559 countsByYear W20532945592023 @default.
• W2053294559 crossrefType "journal-article" @default.
• W2053294559 hasAuthorship W2053294559A5032512383 @default.
• W2053294559 hasAuthorship W2053294559A5066638505 @default.
• W2053294559 hasAuthorship W2053294559A5086851939 @default.
• W2053294559 hasBestOaLocation W20532945592 @default.
• W2053294559 hasConcept C134897094 @default.
• W2053294559 hasConcept C142724271 @default.
• W2053294559 hasConcept C147483822 @default.
• W2053294559 hasConcept C159654299 @default.
• W2053294559 hasConcept C163764329 @default.
• W2053294559 hasConcept C203014093 @default.
• W2053294559 hasConcept C203565725 @default.
• W2053294559 hasConcept C21194631 @default.

• next