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• W2053295364 abstract "This study was aimed at developing a novel experimental setup to investigate the tensional response of a single living cell to external deformation. We constructed the setup which consisted of three components: a device for applying various patterns of uniaxial deformation to living cells, a mechanical scanning probe microscope (M-SPM), and an optical microscope. Intracellular tension is reflected by cellular stiffness measured by M-SPM. Using the setup, we found that stiffness in some areas on a living fibroblast cell increased while stiffness in other areas decreased under 8% external single-step stretch. Furthermore, we found that repetitive deformation inhibited the increase in the stretch-induced cellular stiffness. The present setup is useful for investigating the characteristics of intracellular tensional responses to external deformation." @default.
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• W2053295364 date "2007-08-23" @default.
• W2053295364 modified "2023-09-27" @default.
• W2053295364 title "Visualization of Stretch-Induced Intracellular Tensional Response of Single Fibroblasts by Mechanical Scanning Probe Microscopy" @default.
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• W2053295364 doi "https://doi.org/10.1143/jjap.46.5631" @default.
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