FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053307900> ?p ?o ?g. }

• W2053307900 endingPage "e576" @default.
• W2053307900 startingPage "e576" @default.
• W2053307900 abstract "The structural complexity of chromosome 1p centromeric region has been an obstacle for fine mapping of tumor suppressor genes in this area. Loss of heterozygosity (LOH) on chromosome 1p is associated with the longer survival of oligodendroglioma (OD) patients. To test the clinical relevance of 1p loss in glioblastomas (GBM) patients and identifiy the underlying tumor suppressor locus, we constructed a somatic deletion map on chromosome 1p in 26 OG and 118 GBM. Deletion hotspots at 4 microsatellite markers located at 1p36.3, 1p36.1, 1p22 and 1p11 defined 10 distinct haplotypes that were related to patient survival. We found that loss of 1p centromeric marker D1S2696 within NOTCH2 intron 12 was associated with favorable prognosis in OD (P = 0.0007) as well as in GBM (P = 0.0175), while 19q loss, concomitant with 1p LOH in OD, had no influence on GBM survival (P = 0.918). Assessment of the intra-chromosomal ratio between NOTCH2 and its 1q21 pericentric duplication N2N (N2/N2N-test) allowed delineation of a consistent centromeric breakpoint in OD that also contained a minimally lost area in GBM. OD and GBM showed distinct deletion patterns that converged to the NOTCH2 gene in both glioma subtypes. Moreover, the N2/N2N-test disclosed homozygous deletions of NOTCH2 in primary OD. The N2/N2N test distinguished OD from GBM with a specificity of 100% and a sensitivity of 97%. Combined assessment of NOTCH2 genetic markers D1S2696 and N2/N2N predicted 24-month survival with an accuracy (0.925) that is equivalent to histological classification combined with the D1S2696 status (0.954) and higher than current genetic evaluation by 1p/19q LOH (0.762). Our data propose NOTCH2 as a powerful new molecular test to detect prognostically favorable gliomas." @default.
• W2053307900 created "2016-06-24" @default.
• W2053307900 creator A5000116371 @default.
• W2053307900 creator A5002171069 @default.
• W2053307900 creator A5008303358 @default.
• W2053307900 creator A5013012959 @default.
• W2053307900 creator A5014129073 @default.
• W2053307900 creator A5014940156 @default.
• W2053307900 creator A5022059030 @default.
• W2053307900 creator A5040232100 @default.
• W2053307900 creator A5049661252 @default.
• W2053307900 creator A5061080985 @default.
• W2053307900 creator A5072870176 @default.
• W2053307900 creator A5076191373 @default.
• W2053307900 creator A5076197620 @default.
• W2053307900 creator A5080160564 @default.
• W2053307900 date "2007-06-27" @default.
• W2053307900 modified "2023-10-15" @default.
• W2053307900 title "Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain Tumors" @default.
• W2053307900 cites W1522230447 @default.
• W2053307900 cites W1878193927 @default.
• W2053307900 cites W1965265115 @default.
• W2053307900 cites W1967189264 @default.
• W2053307900 cites W197014098 @default.
• W2053307900 cites W1972745483 @default.
• W2053307900 cites W1989858049 @default.
• W2053307900 cites W1995004385 @default.
• W2053307900 cites W2001493754 @default.
• W2053307900 cites W2018527149 @default.
• W2053307900 cites W2020467756 @default.
• W2053307900 cites W2021816624 @default.
• W2053307900 cites W2025504334 @default.
• W2053307900 cites W2030964595 @default.
• W2053307900 cites W2038659997 @default.
• W2053307900 cites W2047296435 @default.
• W2053307900 cites W2085259586 @default.
• W2053307900 cites W2085682228 @default.
• W2053307900 cites W2103672421 @default.
• W2053307900 cites W2105526612 @default.
• W2053307900 cites W2113942802 @default.
• W2053307900 cites W2114998237 @default.
• W2053307900 cites W2115074304 @default.
• W2053307900 cites W2117383442 @default.
• W2053307900 cites W2142527842 @default.
• W2053307900 cites W2145247163 @default.
• W2053307900 cites W2149864958 @default.
• W2053307900 cites W2154861644 @default.
• W2053307900 cites W2158370459 @default.
• W2053307900 cites W2162184748 @default.
• W2053307900 cites W2168298750 @default.
• W2053307900 cites W2168908657 @default.
• W2053307900 cites W2315751647 @default.
• W2053307900 cites W2333825803 @default.
• W2053307900 cites W37630318 @default.
• W2053307900 doi "https://doi.org/10.1371/journal.pone.0000576" @default.
• W2053307900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1892807" @default.
• W2053307900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17593975" @default.
• W2053307900 hasPublicationYear "2007" @default.
• W2053307900 type Work @default.
• W2053307900 sameAs 2053307900 @default.
• W2053307900 citedByCount "61" @default.
• W2053307900 countsByYear W20533079002012 @default.
• W2053307900 countsByYear W20533079002013 @default.
• W2053307900 countsByYear W20533079002014 @default.
• W2053307900 countsByYear W20533079002015 @default.
• W2053307900 countsByYear W20533079002016 @default.
• W2053307900 countsByYear W20533079002017 @default.
• W2053307900 countsByYear W20533079002018 @default.
• W2053307900 countsByYear W20533079002019 @default.
• W2053307900 countsByYear W20533079002020 @default.
• W2053307900 countsByYear W20533079002022 @default.
• W2053307900 crossrefType "journal-article" @default.
• W2053307900 hasAuthorship W2053307900A5000116371 @default.
• W2053307900 hasAuthorship W2053307900A5002171069 @default.
• W2053307900 hasAuthorship W2053307900A5008303358 @default.
• W2053307900 hasAuthorship W2053307900A5013012959 @default.
• W2053307900 hasAuthorship W2053307900A5014129073 @default.
• W2053307900 hasAuthorship W2053307900A5014940156 @default.
• W2053307900 hasAuthorship W2053307900A5022059030 @default.
• W2053307900 hasAuthorship W2053307900A5040232100 @default.
• W2053307900 hasAuthorship W2053307900A5049661252 @default.
• W2053307900 hasAuthorship W2053307900A5061080985 @default.
• W2053307900 hasAuthorship W2053307900A5072870176 @default.
• W2053307900 hasAuthorship W2053307900A5076191373 @default.
• W2053307900 hasAuthorship W2053307900A5076197620 @default.
• W2053307900 hasAuthorship W2053307900A5080160564 @default.
• W2053307900 hasBestOaLocation W20533079001 @default.
• W2053307900 hasConcept C104317684 @default.
• W2053307900 hasConcept C142724271 @default.
• W2053307900 hasConcept C143589142 @default.
• W2053307900 hasConcept C180754005 @default.
• W2053307900 hasConcept C206936463 @default.
• W2053307900 hasConcept C2777931997 @default.
• W2053307900 hasConcept C2778227246 @default.
• W2053307900 hasConcept C2778880634 @default.
• W2053307900 hasConcept C2910535243 @default.
• W2053307900 hasConcept C30481170 @default.
• W2053307900 hasConcept C502942594 @default.

• next